肝脏研究（英文）2025，Vol.9Issue(2)：144-156,13.DOI:10.1016/j.livres.2025.05.002
Single-cell transcriptomic insights into endosulfan-induced liver injury:Key pathways and inflammatory responses
Single-cell transcriptomic insights into endosulfan-induced liver injury:Key pathways and inflammatory responses
Pan Huang 1Jigang Wang 2Yunmeng Bai 3Chaohua Zhou 3Xiaoru Zhong 3Ashok Iyaswamy 4Peng Chen 5Xu Wei 6Wei Zhang 7Chuanbin Yang3
作者信息
- 1. Department of Epidemiology,School of Public Health,Guangxi Medical University,Nanning,Guangxi,China
- 2. Department of Epidemiology,School of Public Health,Guangxi Medical University,Nanning,Guangxi,China||Department of Critical Care Medicine,Guangdong Provincial Clinical Research Center for Geriatrics,Shenzhen Clinical Research Center for Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University||The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong,China||Center for Drug Research and Development,Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations,Guangdong Pharmaceutical University,Guangzhou,Guangdong,China||State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China
- 3. Department of Critical Care Medicine,Guangdong Provincial Clinical Research Center for Geriatrics,Shenzhen Clinical Research Center for Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University||The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong,China
- 4. Mr.and Mrs.Ko Chi-Ming Centre for Parkinson's Disease Research,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong SAR,China||Department of Biochemistry,Karpagam Academy of Higher Education,Coimbatore,India
- 5. Experimental Research Center,China Academy of Traditional Chinese Medicine,Beijing,China
- 6. Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing,China
- 7. Center for Drug Research and Development,Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations,Guangdong Pharmaceutical University,Guangzhou,Guangdong,China||Department of Critical Care,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,China
- 折叠
摘要
关键词
Endosulfan(ENDO)/Liver injury/hepatotoxicity/Single-cell RNA sequencing(scRNA-seq)/Inflammatory responses/Intercellular communication/Hepatic microenvironmentKey words
Endosulfan(ENDO)/Liver injury/hepatotoxicity/Single-cell RNA sequencing(scRNA-seq)/Inflammatory responses/Intercellular communication/Hepatic microenvironment引用本文复制引用
Pan Huang,Jigang Wang,Yunmeng Bai,Chaohua Zhou,Xiaoru Zhong,Ashok Iyaswamy,Peng Chen,Xu Wei,Wei Zhang,Chuanbin Yang..Single-cell transcriptomic insights into endosulfan-induced liver injury:Key pathways and inflammatory responses[J].肝脏研究（英文）,2025,9(2):144-156,13.基金项目
The work was supported by grants from the National Key Research and Development Program of China(No.2022YFC2303603 and 2020YFA0908004),the Shenzhen Science and Technology Program(Nos.JCYJ20220818102613029,JCYJ20240813175901003,and JCYJ20240813103823031),China Postdoctoral Science Foundation(No.2024M752143),the Shenz-hen Medical Research Funds(No.B2302051),the Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023D003 and CI2023E005TS05),the CACMS Innovation Fund(CI2023E002 and ZG2024001-05),the Funda-mental Research Funds for the Central public welfare research in-stitutes(ZZ13-ZD-07,ZZ14-YQ-050,ZZ14-FL-010,ZZ14-ND-010,ZZ15-ND-10,ZZ16-ND-10-23,ZZ17-ND-10 and ZZ18-ND-10). （No.2022YFC2303603 and 2020YFA0908004）
