首页|期刊导航|郑州大学学报（医学版）|中国食管腺癌淋巴结和血道转移与临床病理特征及预后的关系

中国食管腺癌淋巴结和血道转移与临床病理特征及预后的关系

王立东范宗民韩雪娜尹艳春雷玲玲韩文莉秦富强李爱丽王献增王五洲李吉林陶潇龙马磊徐全晓罗宏李秀敏张冬云纪爱芳宋昕高慧丽张晓倩赵学科卢玉娴张占阳王苒

郑州大学学报（医学版）2025，Vol.60Issue(4)：473-477,5.

郑州大学学报（医学版）2025，Vol.60Issue(4)：473-477,5.DOI:10.13705/j.issn.1671-6825.2024.10.022

中国食管腺癌淋巴结和血道转移与临床病理特征及预后的关系

Association of lymph node and hematogenous metastasis with clinicopath-ological feature and prognosis of esophageal adenocarcinoma in China

王立东 ¹范宗民 ¹韩雪娜 ¹尹艳春 ¹雷玲玲 ¹韩文莉 ¹秦富强 ²李爱丽 ³王献增 ⁴王五洲 ⁵李吉林 ⁶陶潇龙 ¹马磊 ⁷徐全晓 ⁷罗宏 ⁸李秀敏 ⁹张冬云 ¹⁰纪爱芳 ¹¹宋昕 ¹高慧丽 ¹²张晓倩 ¹²赵学科 ¹卢玉娴 ¹²张占阳 ¹²王苒¹

作者信息

1. 郑州大学第一附属医院河南省食管癌重点开放实验室||代谢紊乱与食管癌防治全国重点实验室郑州 450052
2. 林州市肿瘤医院眼科河南林州 456550
3. 林州市肿瘤医院肿瘤科河南林州 456550
4. 林州市人民医院胸外科河南林州 456550
5. 林州市人民医院神经内科河南林州 456550
6. 林州市人民医院病理科河南林州 456550
7. 南阳市第一人民医院河南省肿瘤分子生物学医学重点实验室河南南阳 473000
8. 光山县人民医院普外科河南光山 465499
9. 新乡医学院新乡市肿瘤分子治疗重点实验室河南新乡 453003
10. 南阳医学高等专科学校基础医学部病理教研室河南南阳 473000
11. 长治医学院附属和平医院检验科山西长治 046000
12. 郑州大学第一附属医院河南省食管癌重点开放实验室||代谢紊乱与食管癌防治全国重点实验室郑州 450052||郑州大学医学科学院郑州 450052
折叠

摘要

Abstract

Aim:To investigate the association of lymph node and hematogenous metastasis with the clinicopathological feature and prognosis of esophageal adenocarcinoma(EAC)in China.Methods:Totally 600 cases with EAC were selected from the database of clinical pathology and follow-up(since 1973)of 700 000 cases of esophageal cancer patients in Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital of Zhengzhou University.The clinicopatho-logical features of patients with positive and negative lymph node metastasis(LNM)or vascular tumour embolism(VTE)were compared.Kaplan-Meier and Cox regression analysis were used to explore the association of both with the prognosis of EAC.Results:Out of the 600 cases,LNM was identified in 340 cases(56.7％),while VTE in 262 cases(43.7％).The proportions of male patients,those with smoking history,drinking history,family history,lower thoracic segment,poorly dif-ferentiation and T3/T4 stage in the LNM positive group were greater than those in the negative group(P＜0.05).The pro-portions of male patients,those at high-incidence areas,those with family history,lower thoracic segment,poorly differentia-tion and T3/T4 stage in the VTE positive group were greater than those in the negative group(P＜0.05).There were 213 cases of LNM+VTE+,211 cases of LNM-VTE-,127 cases of LNM+VTE-,and 49 cases of LNM-VTE+.The prognosis of the LNM-VTE-group was better than that of the LNM+VTE-and LNM+VTE+groups(P＜0.001).Cox regression a-nalysis showed that after adjusting for multiple factors,compared with LNM-VTE-,LNM-VTE+,LNM+VTE-,and LNM+VTE+patients had increased risk of death,with HR(95％CI)of 1.496(0.980-2.285),2.019(1.483-2.748),and 2.642(2.013-3.467).Conclusion:LNM and VTE may be associated with the death risk for EAC and should be included in the prognostic assessment system.

关键词

食管腺癌/淋巴结转移/血道转移/脉管癌栓

Key words

esophageal adenocarcinoma/lymph node metastasis/hematogenous metastasis/vascular tumour embolism

分类

医药卫生

引用本文复制引用

王立东,范宗民,韩雪娜,尹艳春,雷玲玲,韩文莉,秦富强,李爱丽,王献增,王五洲,李吉林,陶潇龙,马磊,徐全晓,罗宏,李秀敏,张冬云,纪爱芳,宋昕,高慧丽,张晓倩,赵学科,卢玉娴,张占阳,王苒..中国食管腺癌淋巴结和血道转移与临床病理特征及预后的关系[J].郑州大学学报（医学版）,2025,60(4):473-477,5.

基金项目

国家科技重大专项(2024ZD0520906) （2024ZD0520906）

国家自然科学基金项目(U1301227) （U1301227）

河南省科技攻关项目(232102311032) （232102311032）

郑州大学学报（医学版）

OA北大核心

ISSN：1671-6825

访问量0

下载量0

段落导航