中国当代医药2025，Vol.32Issue(17)：28-31,36,5.DOI:10.3969/j.issn.1674-4721.2025.17.06
阿利西尤单抗在脑梗死患者中的应用效果及对血脂、颈动脉斑块的影响
Application effect of Alirocumab in patients with cerebral infarction and its effect on blood lipids and carotid plaque
官建华 1倪云凤2
作者信息
- 1. 福建医科大学附属协和医院脑血管病科,福建 福州 350001
- 2. 福建中医药大学附属第二人民医院脑病科,福建 福州 350003
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy of Alirocumab in the treatment of cerebral infarction(CI)and its effect on blood lipids and carotid plaque.Methods A total of 70 CI patients admitted to the Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from July 2023 to July 2024 were enrolled in the study.They were divided into the treatment group(n=35)and the control group(n=35)using the random number table medthod.The control group received oral lipid-lowering drugs,while the treatment group received additional subcutaneous injections of Alirocumab.The neurological function,blood lipid levels,carotid plaque,and adverse reactions were compared between the two groups before and after intervention.Results The National Institutes of Health stroke scale(NIHSS)score at 1 week post-intervention and the modified Rankin scale(mRS)score at 3 months post-intervention in the treatment group were lower than those in the control group,with statistically significant differences(P＜0.05).The total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)at 3 months post-intervention in the treatment group were lower than those in the control group,while high-density lipoprotein cholesterol(HDL-C)were higher than those in the control group,with statistically significant differences(P＜0.05).The carotid plaque area(PA),plaque score(Course score),and intima-media thickness(IMT)of the carotid artery at 3 months post-intervention in the treatment group were lower than those in the control group,with statistically significant differences(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Treatment with Alirocumab can significantly improve the neurological function and clinical prognosis of patients with CI,have a comprehensive regulatory effect on blood lipids,and help to reshape carotid plaque,with good safety.关键词
阿利西尤单抗/脑梗死/神经功能/血脂/颈动脉斑块Key words
Alirocumab/Cerebral infarction/Neurologi-cal function/Blood lipid/Carotid plaque分类
医药卫生引用本文复制引用
官建华,倪云凤..阿利西尤单抗在脑梗死患者中的应用效果及对血脂、颈动脉斑块的影响[J].中国当代医药,2025,32(17):28-31,36,5.
