江西农业大学学报2025，Vol.47Issue(3)：650-658,9.DOI:10.3724/aauj.2025056
酰基酚酸衍生物的合成、结构表征与抗真菌活性
Synthesis,structures and antifungal activity of acyl phenolic acid derivatives
摘要
Abstract
[Objective]Phenolic acid is a plant active ingredient with antibacterial activity,and how to improve its antibacterial activity has been widely concerned.[Method]Nine acyl phenolic acid derivatives were synthesized by the reaction of methyl p-hydroxybenzoate,methyl vanillic acid and methyl syringate with phenolic hydroxyl as active site and three anhydrides.The structure of the target compound was characterized by NMR,MS and single crystal diffraction,and the antifungal activities of nine acyl phenolic acid derivatives against fourteen pathogenic fungi were studied by mycelium growth method.[Result]The test results indicate that acylphenolic acid derivatives exhibit certain antimicrobial activity against 14 pathogenic fungi.Compound A7 exhibits the best antibacterial activity against Rhizoctonia solani Kühn and citrus Colletotrichum gloeosporioides,with IC50 of 52.894 mg/L and 78.630 mg/L,respectively.Compound A5 exhibits the best antibacterial activity against Rhizoctonia solani,and its IC50 is 27.041 mg/L.[Conclusion]Two phenolic acid derivatives with high antifungal activity were obtained by research screening,which provided ideas and theoretical bacteriostasis for the development of botanical fungicides.关键词
酚酸衍生物/合成/结构表征/抑菌活性Key words
phenolic acid derivatives/synthesis/structural characterization/antifungal activity分类
农业科技引用本文复制引用
聂旭亮,张苗苗,肖攀蕾,王贵书,彭大勇..酰基酚酸衍生物的合成、结构表征与抗真菌活性[J].江西农业大学学报,2025,47(3):650-658,9.基金项目
国家自然科学基金项目(32160660)Project supported by the National Natural Science Foundation of China(32160660) 江西省教育厅基金项目(GJJ200404,JXJG-24-3-1)和江西省药品监督管理局基金项目(2022JS34)同时对本研究给予了资助,谨致谢意! （32160660）
