兰州大学学报（医学版）2025，Vol.51Issue(5)：24-30,7.DOI:10.13885/j.issn.1000-2812.2025.05.004
不同营养状态儿童营养素摄入与肠道微生物分布影响研究
Study on the effects of nutrient intake and intestinal microecolo-gy distribution of children with different nutritional status
摘要
Abstract
Objective To explore the relationship between nutrient intake and intestinal microorganisms with children's nutritional status,in order to provide a basis for scientific feeding of children.Methods We collect-ed children's dietary information through 24-hour meal review method and food frequency survey method for dietary analysis;high-throughput gene sequencing technology was applied to detect the distribution of mi-croorganisms in the feces of normal-nutritional,malnutritional and overweight-obese children,to analyze the differences in intestinal microecology among children with different nutritional status,and to perform nutrient intake correlation analysis.Results There were differences in carbohydrate,sodium,vitamin C,and purine intake among children with different nutritional status(P<0.05).Children's weight was positively corre-lated with intake of energy,protein,carbohydrate,dietary fiber,copper,sodium,vitamin B1,niacin,folate,iodine,and purine(P<0.05);children's height was positively correlated with intake of protein,carbohy-drate,dietary fiber,copper,manganese,sodium,vitamin B1,niacin,folate,and iodine,purine intake were positively corre-lated(P<0.05).There were significant differences in the relative abundance of species of intestinal microor-ganisms in children with different nutritional status;Bacteroidetes and Actinobacteria were significantly(P<0.05)increased in the overweight and obese group(34.16%and 18.41%)as compared to the normal group(29.96%and 2.54%)and the malnutrition group(21.36%and 15.76%),whereas the relative abundance of Pseudomonas was significantly(P<0.05)increased in normal group(25.79%)as compared to overweight obese group(15.99%)and malnourished group(19.63%).Conclusion The proportion of nutrient intake af-fects the nutritional status of children,and it is necessary to pay attention to the proportion of macro-nutrient intake and the intake of micronutrients in children,use nutrient supplements reasonably when neces-sary,and feed them reasonably so as to safeguard the healthy growth and development of children.关键词
儿童/营养状况/营养素/肠道微生物/科学喂养/微量元素Key words
children/nutritional status/nutrient/intestinal microorganisms/scientific feeding/trace element分类
医药卫生引用本文复制引用
张永花,石影,王金艳,王克玲,白桂林,高鹏..不同营养状态儿童营养素摄入与肠道微生物分布影响研究[J].兰州大学学报（医学版）,2025,51(5):24-30,7.基金项目
兰州市科技计划资助项目(2022-2-108,2022-5-157) （2022-2-108,2022-5-157）
