中国当代医药2025，Vol.32Issue(16)：14-19,6.DOI:10.3969/j.issn.1674-4721.2025.16.03
枇杷止咳颗粒薄荷脑β-环糊精包合工艺及质量评价研究
Research on the inclusion process and quality evaluation of menthol β-cy-clodextrin in Pipa Zhike Granules
摘要
Abstract
Objective The aim is to improve the stability of menthol in the prescription of loquat cough relieving granules,clarify the process parameters of menthol β-cyclodextrin inclusion,and establish the characteristic map of loquat cough re-lieving granules and the quality evaluation method of menthol content determination.Methods The stability of menthol in the prescription was enhanced by using the β-cyclodextrin inclusion technique.The characteristic map examination method of Pipa Zhike Granules was established by high performance liquid chromatography,and the content determination method of β-cyclodextrin inclusion menthol was constructed by gas chromatography.Results The average metastasis rate of menthol in the prescription of Loquat Cough Granules increased from 15％to 73％,and the stability of menthol encapsulated byβ-cyclodextrin was good.In the check of the characteristic spectra,A total of 13 characteristic peaks were determined us-ing chlorogenic acid and picoside A as reference peaks,and 4 chemical components among them were identified.In terms of the determination of menthol content,the linear relationship of menthol was good within the range of 41.13-205.63 μg/ml.The RSD of the test results of precision,repeatability and stability were all less than 2.0％,and the recovery rate of sample addition was 97.6％.Conclusion In this study,the inclusion process parameters of menthol β-cyclodextrin were deter-mined,and the methods for the determination of menthol content and the inspection of characteristic spectra were established,providing strong support for ensuring the stable quality of Pipa Zhike Granules.关键词
枇杷止咳颗粒/β-环糊精包合/薄荷脑/特征图谱/质量评价Key words
Pipa Zhike Granules/β-Cyclodextrin inclusion/Characteristic atlas/Menthol/Quality evaluation分类
医药卫生引用本文复制引用
沈硕,赵文玉,余俊,左言东,吕迎四,王莉莉,汪道顺..枇杷止咳颗粒薄荷脑β-环糊精包合工艺及质量评价研究[J].中国当代医药,2025,32(16):14-19,6.基金项目
安徽省药品监督管理局科技创新项目(AHYJ-KJ202221). （AHYJ-KJ202221）
