日用化学工业（中英文）2025，Vol.55Issue(7)：844-852,9.DOI:10.3969/j.issn.2097-2806.2025.07.004
复方精油-乳酸防脱育发微乳的制备工艺及药效作用研究
Research on the preparation process and pharmacodynamic effect of compound essential oil-lactic acid anti-hair loss microemulsion
摘要
Abstract
This study utilizes a lactic acid solution,which promotes hair growth,as the aqueous phase,and compound essential oil as the oil phase,to prepare an O/W microemulsion for preventing hair loss and promoting hair growth.The formulation of the microemulsion was optimized using a pseudo-ternary phase diagram combined with the Box-Behnken response surface method,evaluating particle size and PDI as indicators to obtain the best preparation process.A seborrheic alopecia animal model was established using C57BL/6 mice to evaluate the effects of the microemulsion on hair loss prevention and hair growth.The results indicate that the optimal formulation of the microemulsion comprise 9.29%oil phase,21.32%Tween 80,10.66%anhydrous ethanol,and 58.71%aqueous phase,yielding an average particle size of 16.48 nm and a PDI of 0.038.The microemulsion exhibits good centrifugation and temperature stability.The formulation significantly increases hair length and weight in mice(P<0.05),improves the number and distribution of hair follicles,upregulates the concentrations of KGF and VEGF in mouse skin,and decreases the concentration of TGF-β1(P<0.05).This study provides a basis for the development of new formulations containing essential oils for hair loss prevention and promotion.关键词
乳酸/复方精油/微乳/响应面法/脂溢性脱发Key words
lactic acid/essential oil of traditional Chinese medicine/microemulsion/Box-Behnken/seborrheic alopecia分类
化学化工引用本文复制引用
熊耀坤,杨思,洪石希,张浩朗,李良骥,陈宇欢..复方精油-乳酸防脱育发微乳的制备工艺及药效作用研究[J].日用化学工业（中英文）,2025,55(7):844-852,9.基金项目
国家自然科学基金项目(82460771) （82460771）
江西杰出青年基金项目(20224ACB216017) （20224ACB216017）
江西省自然科学基金青年项目(20212BAB215023) （20212BAB215023）
江西中医药大学校级创新专项项目(JZYC23S65) （JZYC23S65）
江西中医药大学大学生创新创业训计划项目(202310412030) （202310412030）
