山西医科大学学报2025，Vol.56Issue(6)：644-649,6.DOI:10.13753/j.issn.1007-6611.2025.06.008
原发性高血压患者IL-10和IL-18与左室几何构型及功能的相关性
Relationships of IL-10 and IL-18 levels with left ventricular geometry and function in patients with primary hypertension
摘要
Abstract
Objective To investigate the correlations between interleukin-10(IL-10),interleukin-18(IL-18),and left ventricular geo-metry(LVG),left ventricular function in patients with primary hypertension(PHT).Methods A total of 224 PHT patients in the First Hospital of Shanxi Medical University from July 2023 to May 2024 were enrolled and divided into four groups:normal geometry(NG,n=127),concentric remodeling(CR,n=51),eccentric hypertrophy(EH,n=27),and concentric hypertrophy(CH,n=19).Ad-ditionally,25 age-and sex-matched healthy individuals without hypertension,cardiovascular diseases,or metabolic disorders were re-cruited from the health examination center as control group.General clinical data,serum IL-10 and IL-18 levels,and left ventricular parameters,including left ventricular end-diastolic diameter(LVEDD),interventricular septal thickness(IVST),left ventricular pos-terior wall thickness(LVPWT),left atrial diameter(LAD),left ventricular mass index(LVMI),relative wall thickness(RWT),peak early diastolic flow velocity of the mitral valve orifice(E),peak late diastolic flow velocity of the mitral valve orifice(A),E/A ratio,peak early diastolic mitral annular velocity(e'),E/e'ratio,left ventricular ejection fraction(LVEF),and global longitudinal strain(GLS)were compared among the five groups.Pearson correlation and multivariate Logistic regression analyses were used to evaluate the associations of IL-10 and IL-18 with LVG and left ventricular function.Results Compared with control group,serum IL-10 level decreased while IL-18 level increased in PHT groups(all P<0.05),especially EH group and CH group(all P<0.05).Pearson correlation analysis revealed that IL-10 was negatively correlated with LVEDD,IVST,LVPWT,A,and E/e'(P<0.05),and positively correlated with e',E/A,LVEF,and GLS(P<0.05).Conversely,IL-18 was positively correlated with LVEDD,IVST,LVPWT,A,and E/e'(P<0.05),and negatively correlated with e',E/A,LVEF,and GLS(P<0.05).Multivariable Logistic regression analysis demonstrated that IL-10 was an independent protective factor for CR,EH and CH(P<0.05),whereas IL-18 emerged as an independent risk factor for CR,EH and CH(P<0.05).Conclusion IL-10 and IL-18 are closely related to left ventricular structure and function in PHT pa-tients,suggesting that they may be involved in the process of abnormal left ventricular structure and function in PHT.关键词
原发性高血压/左室几何构型/超声心动描记术/二维应变/白细胞介素-10/白细胞介素-18Key words
primary hypertension/left ventricular geometry/echocardiography/two-dimensional strain/IL-10/IL-18分类
医药卫生引用本文复制引用
李亚楠,水雯,邢雪青,陈耀东,沈文茜,宋庆飞,王健..原发性高血压患者IL-10和IL-18与左室几何构型及功能的相关性[J].山西医科大学学报,2025,56(6):644-649,6.基金项目
国家自然科学基金资助项目(82371989) （82371989）
山西省科技合作交流专项项目(202204041101045) （202204041101045）
