实用肝脏病杂志2025，Vol.28Issue(4)：509-512,4.DOI:10.3969/j.issn.1672-5069.2025.04.008
富马酸替诺福韦二吡呋酯联合当飞利肝宁胶囊治疗慢性乙型肝炎患者临床研究
Clinical observation of tenofovir disoproxil fumarate and Dangfei Liganning capsule in treatment of patients with chronic hepatitis B
摘要
Abstract
Objective The aim of this study was to investigate the clinical efficacy of tenofovir disoproxil fumarate(TDF)and Dangfei Liganning capsule,a herbal medicine compound,in the treatment of patients with chronic hepatitis B(CHB).Methods 97 consecutive patients with CHB were enrolled in our hospital between January 2021 and February 2024,and were randomly assigned to receive TDF in 48 cases in control,or to receive combination of TDF with the herbal medicine in 49 cases for 48 weeks.Serum HBeAg and HBsAg levels were detected by electrochemiluminescence and serum HBV DNA loads were quantitatively measured by real-time PCR.Serum hyaluronic acid(HA),laminin(LN),type Ⅲ procollagen(PCⅢ)and typeⅣ collagen(Ⅳ-C)levels were detected by chemiluminescence,serum interleukin(IL)-6,IL-8,tumor necrosis factor-α and transforming growth factor-β1(TGF-β1)levels were assayed by ELISA,and serum superoxide dismutase(SOD),malondialdehyde(MDA),and nitric oxide(NO)levels were determined by xanthine oxidase,thiobarbituric acid and nitric acid reduction,respectively.Results By end of 48-week treatment,serum ALT and AST levels in combination group were(31.7±6.1)U/L and(39.5±7.3)U/L,both significantly lower than[(39.4±6.3)U/L and(45.3±6.1)U/L,respectively,P＜0.05]in the control;serum HBV DNA in both groups transferred to negative,and there were no significant differences as respect to serum virologic and serologic markers in the two groups(P＜0.05);serum HA,LN and PC Ⅲ levels in the combination group were(186.3±8.2)ng/mL,(171.2±10.4)ng/mL and(158.5±14.7)ng/mL,all much lower than[(292.4±16.7)ng/mL,(230.5±12.7)ng/mL and(181.2±18.6)ng/mL,respectively,P＜0.05]in the control;serum IL-6,IL-8,TNF-α and TGF-β1 levels were(12.9±4.2)μg/L,(5.4±1.0)μg/L,(31.7±9.3)μg/L and(12.6±4.2)ng/L,all significantly lower than[(19.2±4.6)μg/L,(7.1±1.3)μg/L,(49.2±8.6)μg/L and(26.1±4.9)ng/L,respectively,P＜0.05]in the control groups;serum SOD and NO levels were(116.3±17.2)U/mL and(44.2±6.5)μmol/L,both much higher than[(97.4±18.5)U/mL and(37.1±5.9)μmol/L,respectively,P＜0.05],while serum MDA level was(7.1±1.8)nmol/L,much lower than[(9.3±1.5)nmol/L,P＜0.05]in the control group.Conclusion Combination of TDF and Dangfei Liganning capsule has a better efficacy than TDF alone in the treatment of patients with CHB,which might be related to inhibition of liver fibrosis,body's inflammatory reaction and oxidative stress.关键词
慢性乙型肝炎/替诺福韦/当飞利肝宁胶囊/治疗Key words
Hepatitis B/Tenofovir disoproxil fumarate/Dangfei Liganning capsule,a herbal medicine compound/Therapy引用本文复制引用
呙冬慧,陈婷,茅明..富马酸替诺福韦二吡呋酯联合当飞利肝宁胶囊治疗慢性乙型肝炎患者临床研究[J].实用肝脏病杂志,2025,28(4):509-512,4.基金项目
南京医科大科科技发展基金面上项目(编号:2022NJMU260) （编号:2022NJMU260）
