实用肝脏病杂志2025，Vol.28Issue(4)：513-516,4.DOI:10.3969/j.issn.1672-5069.2025.04.009
HBV携带母亲所产婴幼儿对乙肝疫苗接种应答及其影响因素分析
Immune response of infants born to hepatitis B viral infected mothers to hepatitis B vaccination and its influencing factors
摘要
Abstract
Objective The aim of this study was to investigate immunological response of infants born to hepatitis B viral infected mothers to hepatitis B vaccination and its influencing factors.Methods 86 HBV-infected pregnant women and their 86 infants were encountered in our hospital between January 2019 and December 2020,and out of the 86 hepatitis B viral carriers,64 women received oral tenofovir at 28 gestational week for blocking hepatitis B viral mother-to-infant transmission until delivering.All infants received hepatitis B immunoglobulin and hepatitis B vaccine routinely,and were followed-up for three years.Serum HBsAg and anti-hepatitis B surface antigen antibody(HBsAb)were detected by ELIS,and serum HBV DNA loads was assayed by PCR.Results By delivery,serum HBV DNA loads transferred to negative in tenofovir-treated women,and by end of three-year follow-up,serum HBsAb positive in 82 infants(95.3％),including weak positive in 16 cases(19.5％)and strong positive in 66 cases(80.5％),and negative in 4 infants(4.7％)in the 86 infants;concomitant diabetes percentage in mother with their infants positive response was much lower than in those with weak response(12.1％vs.31.2％),while birth weights and gestational weeks were significantly heavier than(3442.7±333.1 g vs.3385.4±370.6 g)or longer than(39.3±1.2 w vs.37.4±1.2 w)in weak responders(P＜0.05);multivariate Logistic regression analysis showed that concomitant diabetes,low infant birth weight and short gestational weeks at birth were all the risk factors impacting immunological response(P＜0.05).Conclusion Hepatitis B vaccination might fails in infants who have a hepatitis B viral infection mothers,the surveillance is important and should re-vaccinates sometimes.关键词
乙型肝炎病毒携带者/乙肝疫苗/接种/孕妇/婴幼儿Key words
Hepatitis B viral carriers/Hepatitis B vaccine/Vaccination/Pregnant women/Infants引用本文复制引用
景志英,程艳梅,郭蜜甜..HBV携带母亲所产婴幼儿对乙肝疫苗接种应答及其影响因素分析[J].实用肝脏病杂志,2025,28(4):513-516,4.基金项目
河南省自然科学基金面上项目(编号:222300420466) （编号:222300420466）
