天津中医药大学学报2025，Vol.44Issue(6)：545-553,9.DOI:10.11656/j.issn.1673-9043.2025.06.10
Notch信号通路在心血管疾病中的作用及中药调控机制研究
The Role of the Notch Signaling Pathway in Cardiovascular Diseases and the Regulatory Mechanisms of Traditional Chinese Medicine
摘要
Abstract
The Notch signaling pathway,is a highly conserved and essential mechanism in regulating cell growth,differentiation,development,tissue repair,and organ formation.Its function has been intrinsically linked to the development,growth,and homeostasis of the heart.Nonetheless,several research has shown that dysfunction of the Notch pathway is implicated in the development and progression of some cardiovascular diseases.Traditional Chinese medicine(TCM)has shown promise in treating cardiovascular diseases by regulating factors involved in the pathways that underscore the pathogenesis of the disease.This article summarizes the relationship between the Notch signaling pathway and various cardiovascular diseases while highlighting the regulatory effects of traditional Chinese medicine on the Notch signaling in treating these conditions.By carefully outlining these interactions,we seek to present a concise mechanism of action of traditional Chinese medicine in preventing and treating cardiovascular diseases.关键词
Notch信号通路/心肌梗死/动脉粥样硬化/信号调控Key words
Notch signaling pathway/myocardial infarct/atherosclerosis/signal regulation分类
医药卫生引用本文复制引用
王冀鲁,刘锐,贾福运,Bonsu Opoku Francis,黎瑞巧,冷玲,王少峡,王启隆..Notch信号通路在心血管疾病中的作用及中药调控机制研究[J].天津中医药大学学报,2025,44(6):545-553,9.基金项目
国家重点研发计划项目(2022YFC3501805) （2022YFC3501805）
国家自然科学基金面上项目(82474310). （82474310）
