中国听力语言康复科学杂志2025，Vol.23Issue(4)：352-359,393,9.DOI:10.3969/j.issn.1672-4933.2025.04.003
耳鸣长期声治疗康复标志物探究
Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus
摘要
Abstract
Objective To investigate the long-term efficacy of Tailor-made Notched-Masking Music Training(TNMMT)in treating subjective tinnitus and to identify objective quantitative biomarkers for rehabilitation,providing a scientific basis for objective evaluation of tinnitus and therapeutic outcomes.Methods A multicenter study involving subjective tinnitus patients was conducted.Behavioral data,subjective tinnitus scales,and resting-state electroencephalogram(EEG)data were collected at weeks 0,2,4,and 8 of TNMMT treatment.Results After 8 weeks of TNMMT intervention,subjective tinnitus patients showed significant reductions in Tinnitus Handicap Inventory(THI),Tinnitus Functional Index(TFI),and Visual Analogue Scale(VAS)scores(P<0.05).Over-threshold loudness of tinnitus also decreased significantly(P<0.05).Compared the baseline(week 0),resting-state EEG power spectra at weeks 2,4,and 8 revealed significant differences in Delta wave power spectral density(P<0.05),Additionally,Theta wave power spectra exhibited significant differences between week 0 and weeks 2/8(P<0.05).Regional analysis indicated significant changes in Delta wave power in the frontal,left temporal,and parietal lobes,as well as Theta wave power in the left frontal,right temporal,and left central regions.Correlation analysis demonstrated significant negative associations between THI,TFI,and VAS scores with Delta wave power.Specifically,VAS_L scores correlated significantly with Delta wave power in the right parietal lobe(P<0.05),and TFI scores correlated with Delta power in the left frontal lobe(P<0.05).Conclusion The TNMMT demonstrates efficacy in long-term intervention for subjective tinnitus,with neuroplasticity phenomena observed during the treatment.Significant correlations were identified between delta band power spectral density and subjective rating scales.关键词
耳鸣/切迹掩蔽/个性化声治疗/主观量表/静息态脑电Key words
Tinnitus/Notched-masking/Tailor-made sound therapy/Subjective scale/Resting-state EEG分类
医药卫生引用本文复制引用
宫琴,陈欢,王慧敏,李欣,冀飞,杨华,伊海金..耳鸣长期声治疗康复标志物探究[J].中国听力语言康复科学杂志,2025,23(4):352-359,393,9.基金项目
"十四·五"国家重点研发计划"诊疗装备与生物医用材料"耳鸣评估诊断治疗设备的研发及产业化(2023YFC2416200) （2023YFC2416200）
