中国实验动物学报2025，Vol.33Issue(6)：878-892,15.DOI:10.3969/j.issn.1005-4847.2025.06.010
体表慢性难愈创面动物模型制备及研究进展
Preparation and evaluation of animal models of chronic ulcers on the body surface
摘要
Abstract
Chronic ulcers on the body surface are non-healing wounds.Establishing a suitable animal model of chronic wounds will provide an important tool for research aimed at preventing and understanding the complexity of chronic wound formation and related pathological mechanisms in the human body.Animal wound models are usually constructed by inducing molecular abnormalities via external injury interventions to induce wound formation.Common modeling method include surgical resection,pressure ischemia,drugs,and radiation treatment.The success of model construction can then be evaluated by various monitoring method,such as natural recovery of the wound without intervention,measurement of wound size observation of physical signs,measurement of body mass,organ index,and infrared imaging.Despite the existence of numerous modeling and evaluating method,however,there is currently a lack of unified standards for animal chronic wound models.Researchers should thus choose appropriate modeling and model-evaluation method based on their actual needs,to obtain the best experimental result.关键词
慢性创面/慢性溃疡/难愈性创面/动物模型Key words
chronic wound/chronic ulcer/refractory wound/animal model分类
生物科学引用本文复制引用
孙郑青,元绍爽,赵桐,张宇,张朝晖,徐强..体表慢性难愈创面动物模型制备及研究进展[J].中国实验动物学报,2025,33(6):878-892,15.基金项目
国家自然科学基金(81904211,81573972),天津中医药大学中医疮疡研究所建设项目(津中医科研[2022]6号),国家重点研发计划(2019YFC1709303).Funded by National Natural Science Foundation of China(81904211,81573972),Construction Project of the Traditional Chinese Medicine Institute of Score and Ulcer,Tianjin University of Traditional Chinese Medicine(Jin Chinese Medicine Research[2022]No.6),National Key Research and Development Program of China(2019YFC1709303). （81904211,81573972）
