Abstract
Objective To explore the application effect of rocuronium bromide combined with dexmedetomidine paraspinal nerve block after radical resection of lung cancer.Methods A total of 76 patients who underwent radical resection of lung cancer and were admitted to Fuxin Central Hospital from November 2021 to November 2024 were selected and grouped by the random number table method.25 patients in the control group received conventional tracheal intubation and general anesthesia.Anesthesia induction was performed with sufentanil at 0.4 µg/kg,propofol at 2.0 mg/kg,and rocuonium at 0.75 mg/kg.In group 1 of the test,25 cases were intravenously pumped with 1.0 µg/kg dexmedetomidine 15 minutes before induction on the basis of the control group.The control group was pumped with the same volume of 0.9%sodium chloride injection.Twenty-six patients in Group 2 of the experiment underwent paravertebral nerve block before induction,and then the same anesthesia protocol as that in Group 1 of the experiment was adopted.The onset time of sedation and analgesia,the onset time of muscle relaxation,the duration of muscle relaxation,the time of eye opening,the extubation time,the recovery time of spontaneous breathing,the dosage of propofol during the operation,the dosage of sufentanil within 24 hours after the operation,the intraoperative center rate and the mean arterial pressure(MAP)level,Postoperative Visual Analogue Scale(VAS)score,Brugman Comfort Scale(BCS)score and anesthesia-related time of muscle relaxation,the duration of muscle relaxation,the eye-opening time,the extubation time,the recovery time of adverse reactions were compared among the three groups of patients.Results The onset time of sedation and analgesia,the onset spontaneous breathing,the intraoperative dosage of propofol,and the dosage of sufentanil within 24 hours after surgery in group 1 and Group 2 of the experiment were shorter or lower than those in the control group(P＜0.05).The eye-opening time,extubation time,recovery time of spontaneous breathing,intraoperative dosage of propofol,and dosage of sufentanil within 24 hours after surgery in group 2 of the experiment were shorter or lower than those in group 1 of the experiment(P＜0.05).There was no significant difference in heart rate and MAP levels among the three groups at T0,T1,and T4(P＞0.05).At T2 and T3,the heart rate and MAP levels of the experimental group 2 were lower than those of the experimental group 1 and the control group(P＜0.05),and those of the experimental group 1 were lower than those of the control group(P＜0.05).At 2 h,6 h,12 h,24 h and 48 h after the operation,the VAS score and BCS score of group 2 in the test were lower than those of the control group and group 1 in the test(P＜0.05).At 2 h,6 h and 12 h after the operation,the VAS score and BCS score of group 1 in the test were lower than those of the control group(P＜0.05).The incidence of adverse reactions in Test group 2 and test group 1 was lower than that in the control group(P＜0.05),and there was no significant difference between test group 1 and test Group 2(P＞0.05).Conclusion For patients undergoing radical resection of lung cancer,adding dexmedetomidine before anesthesia induction can increase the onset time and duration of rocuronium muscle relaxation.At the same time,combined with parapvertebral nerve block can further improve the quality of patient recovery,reduce the dosage of anesthetics during and after the operation,alleviate the degree of postoperative pain,enhance comfort,and has a relatively high safety.关键词
罗库溴铵/右美托咪定/椎旁神经阻滞/肺癌根治术/不良反应/苏醒质量Key words
Rocuronium bromide/Dexmedetomidine/Paraspinal nerve block/Radical resection of lung cancer/Adverse reactions/Awakening quality分类
医药卫生
