中国比较医学杂志2025，Vol.35Issue(6)：35-40,6.DOI:10.3969/j.issn.1671-7856.2025.06.004
褪黑素自组装多肽减轻小鼠心肌缺血再灌注损伤
Melatonin self-assembling peptide attenuates myocardial ischemia-reperfusion injury in mice
摘要
Abstract
Objective To design melatonin(Mel)-based nanomedicines(Mel-NMs)and evaluate their therapeutic effects on myocardial ischemia-reperfusion injury in mice.Methods Melatonin self-assembled peptides(Mel-NMs)were synthesized and their structure was characterized by transmission electron microscopy.Mice were divided randomly into five groups:Sham,Model,Mel,NMs,and Mel-NMs,and a myocardial ischemia-reperfusion injury model was established.Mel(5 mg/kg),NMs,or Mel-NMs(containing Mel 5 mg/kg)were administered intraperitoneally 10 minutes prior to reperfusion,and the sham group was treated with an equal volume of solvent.Cardiac function,apoptosis,and oxidative stress markers were assessed 24 hours after reperfusion.Results Transmission electron microscopy revealed that Mel-NMs formed worm-like structures.Treatment with Mel and Mel-NMs significantly improved cardiac function,reduced lactate dehydrogenase and malondialdehyde levels,and enhanced glutathione peroxidase and superoxide dismutase activities(P＜0.05),while also decreasing cardiomyocyte apoptosis(P＜0.05),with greater effects in the Mel-NMs group(P＜0.05).Conclusions Mel-NMs can effectively mitigate myocardial oxidative stress and apoptosis,offering a more potent cardioprotective effect than Mel alone.关键词
心肌缺血再灌注/褪黑素/自组装多肽/氧化应激/凋亡Key words
myocardial ischemia-reperfusion/melatonin/self-assembled peptide/oxidative stress/apoptosis分类
医药卫生引用本文复制引用
王美娟,李娇,李琦,魏丽萍..褪黑素自组装多肽减轻小鼠心肌缺血再灌注损伤[J].中国比较医学杂志,2025,35(6):35-40,6.基金项目
天津市人民医院重点课题(2023YJZD003) （2023YJZD003）
天津市科技计划项目面上项目(23JCYBJC01470) （23JCYBJC01470）
天津市卫生健康委中医中西医结合课题(2023055). （2023055）
