中华耳科学杂志2025，Vol.23Issue(4)：576-580,5.DOI:10.3969/j.issn.1672-2922.2025.04.007
经圆窗内耳开放后不同时间豚鼠听功能电生理变化研究
Changes of Electrophysiological Responses over Time after Round Window Opening in Guinea Pigs
摘要
Abstract
Objective To report changes of auditory evoked potentials before and at different times after opening the round window in guinea pigs.Methods Seven healthy adult guinea pigs(14 ears)were randomly selected to be tested for electrically evoked auditory nerve compound action potentials(ECAP)(n=3,6 ears)or electrically evoked auditory brainstem responses(EABR)(n=4,8 ears)before and immediately and at 1,2,3,4,5 and 10 minute after opening the round window for inner ear exposure.For ECAPs,changes in thresholds and amplitudes of ECAP and electrically evoked summating potential(ESP)at different time points were compared;and for EABRs,thresholds and wave Ⅲ latencies across time were compared.Results After opening the round window,ECAP thresholds increased significantly at 5 and 10 minutes,with no significant differences in EABR threshold and wave Ⅲ latency at all time points.Conclusion Auditory function in healthy guinea pigs can be reduced by opening the round window with a correlation to the duration of cochlear,showing no significant change within 4 minutes but a decline after 5 minutes,potentially causing damage to hearing function.关键词
圆窗/内耳开放/电诱发听神经复合动作电位/电诱发听性脑干反应Key words
round window/opening of the inner ear/electrically evoked auditory nerve compound action potentials/electrically evoked auditory brainstem responses引用本文复制引用
郑文蕊,张斯,王林娥..经圆窗内耳开放后不同时间豚鼠听功能电生理变化研究[J].中华耳科学杂志,2025,23(4):576-580,5.基金项目
北京市科学技术委员会(应用技术研究与开发项目)资助(Z191100007619043) （应用技术研究与开发项目）
