中华耳科学杂志2025，Vol.23Issue(4)：592-596,5.DOI:10.3969/j.issn.1672-2922.2025.04.011
感音神经性耳聋体外模型的研究进展
Progress of Research on in Vitro Modeling of Sensorineural Hearing Loss
摘要
Abstract
Novel drug development,stem cell therapy,and gene therapy based on molecular pathogenesis have provided innovative pathways of treatment for sensorineural hearing loss(SNHL).Construction of in vitro inner ear models serves as a valuable tool for investigating the pathological mechanism and biological therapies of deafness.In vitro inner ear models are used to realize directional differentiation of stem cells toward inner ear cells or organs by regulating signaling pathways at different stages,and to study pathogenesis and treatment of deafness.Thus,we review the development and utilization of in vitro inner ear models in this paper.关键词
感音神经性耳聋/体外模型/毛细胞/内耳类器官Key words
sensorineural hearing loss/in vitro model/hair cell-like cells/inner ear organoids引用本文复制引用
陈一锦,袁永一..感音神经性耳聋体外模型的研究进展[J].中华耳科学杂志,2025,23(4):592-596,5.基金项目
国家自然科学基金(82271177) （82271177）
