中国现代医生2025，Vol.63Issue(17)：16-19,4.DOI:10.3969/j.issn.1673-9701.2025.17.005
CircRNA9226联合肿瘤标志物对肺腺癌的诊断价值研究
Study of diagnostic value of circRNA9226 combined with tumor markers in lung adenocarcinoma
摘要
Abstract
Objective To investigate the value of peripheral blood circRNA9226 combined with tumor markers for the diagnosis of lung adenocarcinoma.Methods A total of 30 patients with lung adenocarcinoma who were admitted to the Affiliated Lihuili Hospital of Ningbo University from December 2022 to January 2023 were selected as case group.Additionally,twenty healthy individuals who underwent physical examinations during the same period were selected as control group.The expression levels of circRNA9226,carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,and albumin(Alb)were compared between two groups.The diagnostic efficacy of circRNA9226 and CEA for lung adenocarcinoma was evaluated by receiver operating characteristic(ROC)curve,and the correlation between circRNA9226 and other indicators was analyzed.Results The peripheral blood circRNA9226 expression levels in case group was higher than that in control group(P＜0.05).The sensitivity of circRNA9226 and CEA for diagnosing lung adenocarcinoma was 83.3％and 46.7％,respectively,with specificity of 90.0％and 100.0％.Area under the curve(AUC)was 0.897 and 0.776,respectively.When both tests were combined,the sensitivity was 93.3％,accuracy was 92.0％,and AUC was 0.918,showing a significant improvement in both sensitivity and accuracy compared to single tests.The correlation analysis results showed that circRNA9226 was positively correlated with CEA concentration(r=0.371,P＜0.05)and negatively correlated with Alb concentration(r=-0.548,P＜0.05).Conclusion Peripheral blood circRNA9226 has advantages in distinguishing lung adenocarcinoma from healthy controls,and combined with CEA can further improve the diagnostic efficacy.关键词
肺腺癌/环状RNA9226/癌胚抗原/白蛋白Key words
Lung adenocarcinoma/Circular RNA9226/Carcinoembryonic antigen/Albumin分类
医药卫生引用本文复制引用
周薇,戚央聪,赵章生,钱丽慧,马幼丽,穆银玉..CircRNA9226联合肿瘤标志物对肺腺癌的诊断价值研究[J].中国现代医生,2025,63(17):16-19,4.基金项目
浙江省医药卫生科技计划项目(2023KY246) （2023KY246）
