中国现代医生2025，Vol.63Issue(17)：25-28,37,5.DOI:10.3969/j.issn.1673-9701.2025.17.007
血清MP-DNA载量联合NK细胞计数评估耐药性肺炎支原体肺炎患儿的免疫特征研究
Study of serum MP-DNA load combined with NK cell count to evaluate immune characteristics in children with drug-resistant Mycoplasma pneumoniae pneumonia
摘要
Abstract
Objective To investigate immune characteristics of non-responsive macrolide-resistant Mycoplasma pneumoniae pneumonia(MPP)and macrolide-susceptible Mycoplasma pneumoniae pneumonia(MSMPP),and the clinical significance of serum Mycoplasma pneumonia DNA load and NK cell count in the course of disease were evaluated.Methods A total of 120 MPP patients hospitalized at Hangzhou Children's Hospital from August 2022 to August 2023 were selected as subjects,they were divided into MSMPP group(n=36)and macrolide-unresponsive MPP(MUMPP)group(n=84)based on whether they were effective within 72h of using macrolide antibiotics.Compare various indicators levels in the first 6 hours after admission between two groups.Multivariate analysis of variance was used for independent risk factors and receiver operating characteristic(ROC)curve analysis was used for diagnostic performance.Results CD4+T,NK,and lgMP-DNA were independent risk factors for predicting whether MPP patients were MUMPP.The area under ROC curve for CD4+T,NK,lgMP-DNA,NK+CD4+T,lgMP-DNA+CD4+T,and lgMP-DNA+NK were 0.684,0.753,0.728,0.803,0.779,and 0.813,respectively.Conclusion Decreased peripheral blood NK cells and high MP-DNA load are important clinical features of drug-resistant Mycoplasma pneumonia,and combined detection can provide important clinical value for subsequent diagnosis and treatment.关键词
NK细胞/MP-DNA/CD4+T细胞/肺炎支原体肺炎Key words
NK cells/MP-DNA/CD4+T cells/Mycoplasma pneumoniae pneumonia分类
医药卫生引用本文复制引用
张开京,黄小慧,吕晓娟,陈俊松..血清MP-DNA载量联合NK细胞计数评估耐药性肺炎支原体肺炎患儿的免疫特征研究[J].中国现代医生,2025,63(17):25-28,37,5.基金项目
浙江省杭州市卫生科技计划一般(A类)项目(A20250201) （A类）
浙江省医药卫生科技计划项目(2021KY929) （2021KY929）
