中医药学报2025，Vol.53Issue(7)：111-115,5.DOI:10.19664/j.cnki.1002-2392.250153
针刺通过NF-κB信号通路调控小胶质细胞活化治疗神经退行性疾病的研究进展
Research Progress on Acupuncture in Regulating Microglial Activation via the NF-κB Signaling Pathway for the Treatment of Neurodegenerative Diseases
摘要
Abstract
Neurodegenerative diseases are a group of disorders that affect the brain and spinal cord,primarily caused by the loss of neurons and their myelin sheaths.The NF-κB signaling pathway is closely related to neurodegenerative diseases.Abnormal activation of NF-κB exacerbates the pathological process of these diseases.Acupuncture therapy may regulate anti-inflammatory factors and anti-apoptotic proteins,reduce the expression of NF-κB proteins,alleviate excessive microglial activation,suppress neuroinflammation,decrease neuronal apoptosis,and protect neurological function,thereby alleviating the symptoms of neurodegenerative diseases.Based on the NF-κB signaling pathway and microglial cells as the entry point,this review analyzes existing literature and clinical studies to explore acupuncture's potential role in enhancing cognitive function remodeling and restoring motor abilities in patients.Furthermore,the mechanisms of acupuncture in neurodegenerative diseases are discussed,highlighting current research issues and limitations,and offering new targets and ideas for rehabilitation therapy in neurodegenerative diseases.关键词
神经退行性疾病/针刺/NF-κB信号通路/炎症反应/小胶质细胞活化Key words
Neurodegenerative diseases/Acupuncture/NF-κB signaling pathway/Inflammatory response/Microglial activation分类
医药卫生引用本文复制引用
朱钰颖,陈军磊,王婧怡,王维浩,张振国,郑洪博,姚辛敏..针刺通过NF-κB信号通路调控小胶质细胞活化治疗神经退行性疾病的研究进展[J].中医药学报,2025,53(7):111-115,5.基金项目
国家自然科学基金项目(81503478) （81503478）
黑龙江省中医药科研项目(ZYW2024-091) （ZYW2024-091）
黑龙江省自然科学基金联合基金培育项目(PL2024H209) （PL2024H209）
大学生创新创业训练计划项目(国家重点支持领域项目)(202310228063) （国家重点支持领域项目）
大学生创新创业训练项目(国家级一般项目)(202310228031,202410228015,202410228010) （国家级一般项目）
黑龙江中医药大学大学生科技创新项目(KY2022-04,KY2023-10) （KY2022-04,KY2023-10）
