中国现代医生2025，Vol.63Issue(18)：1-4,31,5.DOI:10.3969/j.issn.1673-9701.2025.18.001
帕金森病患者嗅觉障碍影响因素的系统评价
Systematic review of factors influencing olfactory dysfunction in patients with Parkinson's disease
摘要
Abstract
Objective To explore the influencing factors of olfactory dysfunction in patients with Parkinson's disease(PD)and conduct a systematic review and Meta-analysis.Methods Articles on factors influencing olfactory dysfunction in PD were retrieved from databases including SinoMed,VIP,China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform,Web of Science,PubMed,Cochrane,Embase,and MEDLINE.The search period spanned from the inception of each database to November 30,2024.Results A total of 13 articles(with a total sample size of 2465)were included,with a total of 18 influencing factors summarized as two themes:core features and progression factors of PD,and individual background and environmental interaction factors.Meta-analysis showed that age(MD=1.01,95％CI:-0.46-2.49,P=0.18),smoking(OR=0.88,95％CI:0.57-1.37,P=0.57),and constipation(OR=1.22,95％CI:0.38-3.93,P=0.74)were not factors affecting olfactory dysfunction in PD patients.Conclusion Factors influencing olfactory dysfunction in PD are predominantly associated with non-motor symptoms.Intervention strategies targeting non-motor symptoms(such as improving sleep quality,vitamin D supplementation,and early cognitive training)may provide novel approaches for delaying the progression of olfactory dysfunction.关键词
帕金森病/嗅觉障碍/影响因素/系统评价Key words
Parkinson's disease/Olfactory dysfunction/Influencing factors/Systematic review分类
医药卫生引用本文复制引用
刘雨丹,李慧芳,李建春,翟亚仙,杨锦湄,沈云霞..帕金森病患者嗅觉障碍影响因素的系统评价[J].中国现代医生,2025,63(18):1-4,31,5.基金项目
云南省科技厅科技计划项目(202301AZ070001-101) （202301AZ070001-101）
