浙江农业学报2025，Vol.37Issue(5)：1009-1016,8.DOI:10.3969/j.issn.1004-1524.20240827
柳叶蜡梅多糖对大鼠急性胃黏膜损伤的保护机制研究
Gastroprotective effect of polysaccharides extracted from Chimonanthus salicifolius on etha-nol-induced gastric injury in rats
摘要
Abstract
In this study,we established a rat model of ethanol-induced gastric ulcer,to examine the gastroprotective effect of polysaccharides extracted from Chimonanthus salicifolius(CSP),and reveal the related mechanism.It was shown that the main components of CSP were mannose,rhamnose,glucose,galactose and trehalose.Oral gavage with low(200 mg·kg-1,based on body weight)or high(400 mg·kg-1,based on body weight)dose CSP for 28 days prevented the formation of gastric ulcer,as the ulcer index was significantly(P＜0.05)decreased.Compared with the model group,high dose CSP treatment significantly enhanced the activity of superoxide dismutase(SOD)and the contents of prostaglandin E2(PGE2)and epidermal growth factor(EGF),decreased the malonaldehyde(MDA)content,and inhibited the formation of tumour necrosis factor-α(TNF-α),interleukin-6(IL-6)and inter-leukin-1β(IL-1β).CSP could relieve the gastric oxidative stress in rats by regulating the signaling pathways of mi-togen-activated protein kinases(MAPKs)and matrix metalloproteinases(MMPs),hence protect rats from the etha-nol-induced gastric damage.关键词
柳叶蜡梅/多糖/胃溃疡/乙醇Key words
Chimonanthus salicifolius/polysaccharides/gastric ulcer/ethanol分类
农业科技引用本文复制引用
陈琳,顾青..柳叶蜡梅多糖对大鼠急性胃黏膜损伤的保护机制研究[J].浙江农业学报,2025,37(5):1009-1016,8.基金项目
浙江省哲学社会科学规划课题(24NDJC184YB) （24NDJC184YB）
浙江省自然科学基金(LTGN24C200009) （LTGN24C200009）
