中医药学报2025，Vol.53Issue(7)：25-30,6.DOI:10.19664/j.cnki.1002-2392.250136
层次分析法-熵权法结合正交试验优化龙葵素膏成型工艺
Optimization of Solanine Ointment Formulation Process Using Analytic Hierarchy Process-Entropy Weight Method Combined with Orthogonal Test
摘要
Abstract
Objective:To optimize the formulation process of solanine ointment.Methods:The main component α-solanine was extracted from potato peel using ethanol-acetic acid dual-solvent method,and its content was determined by high-performance liquid chromatography(HPLC).Taking viscosity value and subjective evaluation as indicators,a comprehensive score was calculated,and the weight coefficients of each evaluation index were determined using the analytic hierarchy process(AHP)-entropy weight method.Single-factor tests and orthogonal tests were conducted to investigate the effects of the amounts of vaseline,lanolin,and beeswax on the quality of solanine ointment,aiming to determine the optimal formulation parameters.Results:The HPLC results showed that the content of α-solanine in potato peel was 14.81 mg·g-1.The optimal ratio of the oleaginous matrix for solanine ointment was determined as follows:vaseline 10 g,lanolin 0.75 g,and beeswax 0.55 g.Conclusion:The formulation process of solanine ointment is reasonable and feasible,producing a uniform and fine product with good spreadability,thermal/cold resistance,and stability,which provides a theoretical basis for the development and application of solanine.关键词
马铃薯/龙葵素/龙葵素膏/层次分析法-熵权法/成型工艺Key words
Potato/Solanine/Solanine ointment/Analytic hierarchy process-entropy weight method/Formulation process分类
医药卫生引用本文复制引用
褚平铵,郝江峰,彭腾腾,石晓峰,谢兴文,李宁,宋鹏..层次分析法-熵权法结合正交试验优化龙葵素膏成型工艺[J].中医药学报,2025,53(7):25-30,6.基金项目
国家自然科学基金地区科学基金项目(82060873) （82060873）
兰州市人才创新创业项目(2021-RC-88) （2021-RC-88）
甘肃省中医药管理局项目(GZK-2019-25) （GZK-2019-25）
