滨州医学院学报2025，Vol.48Issue(3)：243-248,6.DOI:10.19739/j.cnki.issn1001-9510.2025.03.004
术前雾化吸入右美托咪定对肺叶切除术患者的影响
Preoperative inhalation of dexmedetomidine for patients undergoing lobectomy
摘要
Abstract
Objective To assess the impact of administering dexmedetomidine via aerosol inhalation prior to surgery against its intravenous infusion on key respiratory parameters and overall vital signs in patients undergoing lobectomy under single lung ventilation.Methods A collective of 90 individuals who underwent pulmonary lobotomy(VATS)under intravenous aspiration combined with general anesthesia were selected and divided into the control group(group C),the intravenous group(group I)and the atomization group(group A).Group C Inhaled5 mL of 0.9%sodium chloride solution10 minutes before anesthesia in-duction.In group I,1 μg/kg dexmedetomidine was injected intravenously 10 minutes before induction of anesthesia.In group A,10 minutes before anesthesia induction,1 μg/kg dexmedetomidine was given by atomization.Indicators were collected including gender,age,body mass index(BMI),and invasive systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arte-rial pressure(MAP),heart rate(HR),hemoglobin(Hb),airway pressure(Ppeak),airway plateau pressure(Pplat),oxygen partial pressure(PO2),venous blood oxygen partial pressure(PvO2),mixed venous blood oxygen saturation(SvO2),carbon dioxide partial pressure(PCO2),peripheral oxygen saturation(SpO2),respiratory frequency(RR),and tidal volume(TV)at the beginning of single lung ventilation(T0),30 minutes of single lung ventilation(T1),and 60 minutes of single lung ventila-tion(T2).Additionally,incidences of adverse reactions like shock,bradycardia,and arrhythmias were documented across the three groups.Results Measurements of SBP,DBP,MAP,HR,Ppeak,Pplat,PO2,PvO2,SvO2,PCO2,SpO2,RR,and TV were compared at time points T0,T1,and T2 within all three groups,and the differences were statistically significant(P＜0.05).SBP,DBP,MAP,Ppeak,Pplat,PO2,PvO2,SvO2,PCO2 at T0,T1 and T2 in group A were significantly different from those in group I(P＜0.05).Conclusion Compared with intravenous infusion of dexmedetomidine,atomizing inhalation can signifi-cantly improve most of the patients'hemodynamic and respiratory indicators.关键词
右美托咪定/雾化吸入/肺叶切除术/单肺通气Key words
dexmedetomidine/atomizing inhalation/pulmonary lobectomy/one-lung ventilation分类
医药卫生引用本文复制引用
司文丽,张全意..术前雾化吸入右美托咪定对肺叶切除术患者的影响[J].滨州医学院学报,2025,48(3):243-248,6.基金项目
山东省省级临床重点专科建设项目(SLCZDZK-20) （SLCZDZK-20）
