临床与病理杂志2025，Vol.45Issue(3)：344-353,10.DOI:10.11817/j.issn.2095-6959.2025.240941
铁死亡在慢性伤口中的作用
Role of ferroptosis in chronic wounds
摘要
Abstract
Ferroptosis,a novel iron-dependent form of regulated cell death,plays a pivotal role in the impaired healing of chronic wounds by mediating lipid peroxidation,iron dysregulation,and immune imbalance.In diabetic foot ulcers(DFU),pressure injuries(PI),and chronic venous leg ulcers(CVLU),ferroptosis is activated through distinct yet overlapping mechanisms involving iron metabolism,glutathione peroxidase 4(GPX4)suppression,lipid metabolic alterations,and immune microenvironment remodeling.Several therapeutic approaches targeting ferroptosis—such as iron chelators,antioxidants,immune modulators,and biomaterial-based delivery systems—have demonstrated wound-healing benefits in animal models.Notably,platelet-rich plasma(PRP)has shown clinical promise in promoting ulcer closure and reducing infection rates.Ferroptosis serves as a key pathological amplifier linking inflammation and tissue degradation,and offers tangible therapeutic potential.Integrating ferroptosis-related biomarkers(e.g.,GPX4,ferritin,malondialdehyde)with immune profiling and wound subtype analysis may provide a framework for precision treatment of refractory chronic wounds.关键词
慢性伤口/铁死亡/脂质过氧化/免疫极化/靶向干预Key words
chronic wounds/ferroptosis/lipid peroxidation/immune polarization/targeted intervention引用本文复制引用
董展辰,苏小凤,许珂,蒋艳..铁死亡在慢性伤口中的作用[J].临床与病理杂志,2025,45(3):344-353,10.基金项目
四川省自然科学基金(2024NSFSC1508).This work was supported by the Natural Science Foundation of Sichuan Province,China(2024NSFSC1508). （2024NSFSC1508）
