实用心电与临床诊疗2025，Vol.34Issue(3)：313-318,6.DOI:10.13308/j.issn.2097-5716.2025.03.001
阻塞性睡眠呼吸暂停低通气综合征患者动态动脉硬化指数与脉压、血压变异性的关系
Relationship between ambulatory arterial stiffness index and pulse pressure or blood pressure variability in patients with obstructive sleep apnea hypopnea syndrome
摘要
Abstract
Objective To investigate the correlation between ambulatory arterial stiffness index(AASI)and pulse pressure or blood pressure variability(BPV)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 205 patients specifically diagnosed with OSAHS were enrolled as research objects.They completed general data collection,and polysomnography and ambulatory blood pressure monitoring.Based on the classification of circadian blood pressure rhythm,the study population was divided into a dipper blood pressure group(n=92)and a non-dipper blood pressure group(n=113).We compared the general clinical characteristics between the two groups as well as the correlation between AASI and ambulatory blood pressure parameters by using Pearson correlation analysis.Multiple linear regression analysis was applied to explore the relationship between AASI and pulse pressure or BPV.Results The AASI of the non-dipper blood pressure group was significantly higher than that of the dipper blood pressure group(P＜0.01).AASI was positively correlated with age,24-hour mean systolic blood pressure and pulse pressure,while it was negatively correlated with 24-hour mean diastolic blood pressure,and the decline ratio of nocturnal systolic and diastolic blood pressure(all P＜0.05).Pulse pressure was associated with AASI if BPV remained constant(P＜0.05).Conclusion The AASI of OSAHS patients demonstrates an association with pulse pressure and age.AASI may serve as a promising indicator reflecting arterial stiffness.关键词
阻塞性睡眠呼吸暂停低通气综合征/动态动脉硬化指数/血压变异性/脉压/动脉硬化Key words
obstructive sleep apnea hypopnea syndrome/ambulatory arterial stiffness index/blood pressure variability/pulse pressure/arterial stiffness分类
医药卫生引用本文复制引用
王惠歆,吴毅程,宿燕岗..阻塞性睡眠呼吸暂停低通气综合征患者动态动脉硬化指数与脉压、血压变异性的关系[J].实用心电与临床诊疗,2025,34(3):313-318,6.基金项目
国家自然科学基金面上项目(61971140) （61971140）
福建省财政厅专项课题(闽财指[2023]891) （闽财指[2023]891）
