中国实用神经疾病杂志2025，Vol.28Issue(7)：816-822,7.DOI:10.12083/SYSJ.240379
不同亚型及程度的颈动脉狭窄青年缺血性脑卒中患者NLRP3炎症小体水平分析
Analysis of NLRP3 inflammasome levels in young ischemic stroke patients with different etiological subtypes and carotid artery stenosis degrees
摘要
Abstract
Objective To analyze the levels and clinical significance of NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome in young ischemic stroke(IS)patients with different etiological subtypes and degrees of carotid artery stenosis.Methods A total of 134 young IS patients admitted to Linfen People's Hospital from May 2020 to May 2022 were selected as young stroke group,100 middle-aged and elderly IS patients during the same period were chosen as middle-aged and elderly stroke group,and 100 healthy individuals undergoing physical examinations were included as control group.Traditional risk factors and levels of peripheral blood NLRP3,cysteine protease-1(Caspase-1),apoptosis-associated speck-like protein(ASC),interleukin(IL)-1 β,and IL-18 were compared among the three groups.Serum levels of NLRP3,Caspase-1,ASC,IL-1β,and IL-18 were compared among subgroups based on the Chinese ischemic stroke subclassification(CISS),etiology,and carotid Doppler ultrasound results.Logistic regression analysis was used to identify influencing factors for CISS subtypes and carotid artery stenosis in young IS patients.Results The levels of NLRP3,Caspase-1,ASC,IL-1 β,and IL-18 in the middle-aged and elderly stroke group were significantly higher than those in the young stroke group(P<0.05).LAA-type patients had significantly higher levels of NLRP3,Caspase-1,ASC,IL-1β,and IL-18 compared to PAD,CS,OE,and UE type patients(P<0.05).There were no significant differences in NLRP3,Caspase-1,ASC,IL-1 β,and IL-18 levels among patients with different LAA subtype etiologies(P>0.05).Patients with carotid artery stenosis had significantly higher levels of NLRP3,Caspase-1,ASC,IL-1β,and IL-18 compared to those with normal carotid arteries(P<0.05).Logistic regression analysis indicated that hypertension was an independent risk factor for non-LAA subtypes,while high expressions of NLRP3,Caspase-1,ASC,IL-1β,and IL-18 were independent risk factors for LAA subtype and carotid artery stenosis in young IS patients.Conclusion The high expression of NLRP3 inflammasome is an independent risk factor for young IS and is closely associated with carotid artery stenosis.It plays an important role in large artery atherosclerosis subtypes,suggesting that clinical interventions targeting its expression could improve the patient's prognosis.关键词
缺血性脑卒中/青年/NLRP3炎症小体/CISS分型/大动脉粥样硬化/颈内动脉狭窄/颈部血管彩超/危险因素/预后Key words
Ischemic stroke/Youth/NLRP3 inflammasome/CISS classification/Large-artery atheroscle-rosis/Internal carotid artery stenosis/Carotid Doppler ultrasound/Risk factors/Prognosis分类
医药卫生引用本文复制引用
孙艳花,赵丙瑞,张文敏,张春燕,逯琴,赵敏..不同亚型及程度的颈动脉狭窄青年缺血性脑卒中患者NLRP3炎症小体水平分析[J].中国实用神经疾病杂志,2025,28(7):816-822,7.基金项目
临汾市科技重点研发计划项目(编号:2210) （编号:2210）
