实用心电与临床诊疗2025，Vol.34Issue(3)：348-352,5.DOI:10.13308/j.issn.2097-5716.2025.03.007
益生菌联合定植元对肠道功能紊乱的疗效
Curative effect of probiotics combined with colonization factor on intestinal dysfunction
摘要
Abstract
Objective To explore the influence of colonization factor(CF)on the adhesion of Jiulian probiotics to intestinal mucosal epithelial cells,and the efficacy of Jiulian probiotics combined with CF in treating intestinal dysfunction.Methods Twenty patients with intestinal dysfunction were selected.Based on whether the Jiulian probiotics were co-cultured with intestinal mucosal epithelial cells in combination with CF,they were divided into an experimental group(the Jiulian probiotic suspension was co-cultured with intestinal mucosal epithelial cells in combination with CF)and a control group(only the Jiulian probiotic suspension was co-cultured with intestinal mucosal epithelial cells).Observation was conducted using a self-controlled approach.The Jiulian probiotics that adhered to the intestinal mucosal epithelial cells were extracted separately 4 and 12 hours after co-cultivation;the number of formed colonies was counted,and the effect of CF on promoting the adhesion of the probiotics to the intestinal mucosal epithelial cells was analyzed.According to the gastrointestinal symptom rating scale(GSRS)scores,the curative effect was assessed between the two groups.Results The Jiulian probiotics adherent to cells,harvested from the experimental group after 4 hours of co-cultivation,formed significantly more colonies than those harvested from the control group after 24-hour of cultivation(P＜0.05),while the formed colonies after 12 hours of co-cultivation were significantly more than those harvested from the control group(P＜0.01).After the combination treatment,the GSRS score of the patients was significantly lower than that before the treatment(P＜0.01),while symptoms such as abdominal pain and diarrhea were significantly improved.Conclusion CF could promote the adhesion of Jiulian probiotics to intestinal mucosal epithelial cells.Probiotics combined with CF may become one of effective methods for treating intestinal dysfunction.关键词
九联益生菌/定植元/肠黏膜上皮细胞/肠道功能紊乱Key words
Jiulian probiotic/colonization factor/intestinal mucosal epithelial cell/intestinal dysfunction分类
医药卫生引用本文复制引用
陶立生,朱昕,周永勍,邓兆群,姚俊..益生菌联合定植元对肠道功能紊乱的疗效[J].实用心电与临床诊疗,2025,34(3):348-352,5.基金项目
江苏大学附属人民医院院级重点资助项目(Y2022001-Z) （Y2022001-Z）
