昆明医科大学学报2025，Vol.46Issue(6)：1-8,8.DOI:10.12259/j.issn.2095-610X.S20250601
PINK1/Parkin通路介导的线粒体自噬在神经退行性疾病发展中的影响研究
Impact of PINK1/Parkin-Mediated Mitophagy in the Development of Neurodegenerative Diseases
摘要
Abstract
Mitochondria not only serve as the central hub for cellular energy metabolism,but also participate in crucial physiological processes such as signal transduction and activity regulation.Abnormal mitochondrial quantity,imbalance in mtDNA copy number,accumulation of genetic mutations,and aberrant activation of autophagic pathways can lead to mitochondrial dysfunction or even organelle disorders,while activating mechanisms of cellular damage and death,consequently contributing to the pathogenesis of various diseases.As a highly selective form of autophagy,mitophagy plays a pivotal regulatory role in organelle quality control and homeostasis maintenance.This article focuses on the classic PINK1/Parkin pathway-mediated mitophagy as an entry point,summarizing recent research advances regarding the role of mitophagy in neurodegenerative diseases,aiming to provide novel insights for developing targeted mitophagy regulation strategies to improve prevention and treatment approaches for neurodegenerative disorders.关键词
线粒体自噬/氧化应激/帕金森/阿尔兹海默症Key words
Mitophagy/Oxidative stress/Parkinson's/Alzheimer's disease分类
医药卫生引用本文复制引用
武孔佳,豆舒乾,王媛,王旗,杜攀,刘文军..PINK1/Parkin通路介导的线粒体自噬在神经退行性疾病发展中的影响研究[J].昆明医科大学学报,2025,46(6):1-8,8.基金项目
国家自然科学基金(82460444) （82460444）
昆明医科大学研究生创新基金(2024S280) （2024S280）
