扬州大学学报（农业与生命科学版）2025，Vol.46Issue(3)：65-75,11.DOI:10.16872/j.cnki.1671-4652.2025.03.008
基于网络药理学研究川陈皮素改善小鼠产后抑郁样行为的作用机制
The mechanism of nobiletin in improving postnatal depression-like behavior based on network pharmacology
摘要
Abstract
To explore the mechanism of nobiletin(NOB)in the treatment of postpartum depression using network pharmacology,molecular docking and animal studies.The model of postpartum depression was established and the phar-macological effects of NOB were evaluated by behavior analysis.The targets of nobiletin,postpartum depression,estro-gen withdrawal,and inflammation were obtained from databases such as TCMSP.Protein-protein interaction network was generated using STRING database,and Cytoscape software topology analysis was used to examine the network.Metascape database was applied for GO and KEGG enrichment analysis,and AutoDock Vina was used to complete the molecular docking.Results showed that medium and high doses of NOB significantly improved postpartum depression-like behaviors in mice.A total of 206 intersection genes were obtained by network pharmacological analysis.Core signaling pathways included PI3K-AKT,MAPK and estrogen signaling pathway,etc.Moreover,key targets had good binding activity to NOB.By acting on AKT1,ESR1,BCL2 and others,NOB regulated the PI3K-AKT,MAPK and estrogen signaling pathways to alleviate postpartum depression.This study suggests that NOB may be a potential treatment for postpartum depression.关键词
川陈皮素/网络药理学/分子对接/产后抑郁Key words
nobiletin/network pharmacology/molecular docking/postpartum depression分类
医药卫生引用本文复制引用
何佳奕,向洁,顾有为,许正新,狄婷婷..基于网络药理学研究川陈皮素改善小鼠产后抑郁样行为的作用机制[J].扬州大学学报（农业与生命科学版）,2025,46(3):65-75,11.基金项目
国家自然科学基金资助项目(82301597) （82301597）
扬州大学引进人才科研启动基金项目(137012130) （137012130）
