摘要
Abstract
Inflammatory bowel disease(IBD)is a group of chronic relapsing inflammatory gastrointestinal diseases,including Crohn disease(CD)and ulcerative colitis(UC).30%-50%of IBD patients develop extraintestinal manifestations(EIM),which affect multiple organs such as the musculoskeletal,skin,eyes,and hepatobiliary systems.The occurrence of some EIM parallels the activity of IBD inflammation,while others may progress independently.The pathogenesis of EIM involves multiple factors,including genetic susceptibility,dysbiosis of the gut microbiota,and immune dysregulation.The diagnosis and management of EIM require multidisciplinary team(MDT)collaboration.EIM associated with IBD activity can be alleviated by controlling the underlying IBD,while EIM with independent progression requires individualized treatment strategies according to its pathogenesis.In addition to conventional treatments,tumor necrosis factor(TNF)-α inhibitors are core biological agents suitable for the treatment of most EIM.In the future,precision diagnosis,personalized treatment,and multidisciplinary collaboration will be essential directions in EIM research.关键词
炎症性肠病/肠外表现/多学科团队协作/个体化诊疗Key words
Inflammatory bowel disease/Extraintestinal manifestation/Multidisciplinary team collaboration/Personalized diagnosis and treatment分类
医药卫生
