内科理论与实践2025，Vol.20Issue(2)：120-125,6.DOI:10.16138/j.1673-6087.2025.02.04
中老年人群糖代谢状态与全因死亡及心脑血管疾病死亡风险的关联研究
Association between glucose metabolism and risk of all-cause mortality and cardio-cerebrovascular mortality in middle-aged and elderly populations
摘要
Abstract
Objective To explore the association between different glucose metabolism status and death from all causes,cardio-cerebrovascular diseases in middle-aged and elderly population.Methods Totally 981 community residents aged 35 years and above in Qingpu district,Shanghai were enrolled in 2009 and a 15-year follow-up study of epidemiological survey on type 2 diabetes mellitus(T2DM)among them were conducted.Cox proportional hazards regression model was used to analyze hazard ratio(HR)of all-cause mortality,cardio-cerebrovascular mortality and their 95%CI in middle-aged and elderly population with different glucose metabolism status.Results The cumulative follow-up period was 14 464.01 person-years.During this period,114 subjects died,and all-cause death density were 788.16/100 000 person-years.In which,30 patients were dead from cardio-cerebrovascular diseases,and its death density was 207.41/100 000 person-years.Compared with the population with normal sugar metabolism,the risk of all-cause death in patients with prediabetes increased 77%,all-cause death and cardio-cerebrovascular diseases cause death in T2DM patients increased 155%(HR=2.55,95%CI:1.53-4.25)and 299%(HR=3.99,95%CI:1.52-10.45),respectively.Stratified by age,the risk of cardio-cerebrovascular disease caused death in people under 60 years with prediabetes was higher than that in people with normal glucose metabolism(HR=6.91,95%CI:1.19-40.07),and the risk of all-cause death and cardio-cerebrovascular death in T2DM patient over 60 years was higher than that in people with normal glucose metabolism(HR=2.64,95%CI:1.42-4.90;HR=4.87,95%CI:1.62-14.62).Conclusions Prediabetes and T2DM were important risk factors for all-cause death and cardio-cerebrovascular diseases death in middle-aged and elderly people.Targeted classified prevention and early intervention of blood sugar should be implemented to reduce all-cause death and cardio-cerebrovascular diseases death.关键词
糖尿病前期/2型糖尿病/中老年人/死亡风险/流行病学Key words
Prediabetes/Type 2 diabetes mellitus/Middle-aged and elderly/Risk of death/Epidemiology分类
医药卫生引用本文复制引用
张计委,吴小琼,崔金煌,俞春明,黎衍云..中老年人群糖代谢状态与全因死亡及心脑血管疾病死亡风险的关联研究[J].内科理论与实践,2025,20(2):120-125,6.基金项目
上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科建设项目(GWVI-11.1-20) （2023-2025年）
