器官移植2025，Vol.16Issue(4)：495-501,7.DOI:10.12464/j.issn.1674-7445.2025138
巨噬细胞与异种移植
Macrophages in xenotransplantation
摘要
Abstract
Xenotransplantation is one of the effective ways to overcome the shortage of donor organs.However,the molecular incompatibility between xenotransplantation donors and recipients can cause rejection,which greatly limits the clinical application of xenotransplantation.In recent years,researchers have deeply explored the mechanism of xenotransplantation rejection through xenotransplantation models of pig-to-monkey and pig-to-brain death recipients,and found that the innate immune system plays an important role in rejection.Macrophages,as phagocytes in the innate immune system,not only damage xenografts through phagocytosis but also interact with other immune cells to influence the immune microenvironment of xenotransplantation.However,due to the heterogeneity of macrophages,their phenotypes and functions in xenotransplantation rejection remain unclear.Therefore,it is necessary to further explore the role of macrophages in xenotransplantation rejection.This article reviews the latest research progress of macrophages in xenotransplantation rejection,aiming to explore the mechanisms of macrophages in xenotransplantation rejection and provide references for future research.关键词
巨噬细胞/异种移植/排斥反应/炎症反应/固有免疫/调节性巨噬细胞/凝血失调/信号调节蛋白Key words
Macrophage/Xenotransplantation/Rejection/Inflammation/Innate immunity/Regulatory macrophage/Coagulation dysfunction/Signal regulatory protein分类
医药卫生引用本文复制引用
朱许源,张宇,陈羽翔,李涛,马晓杰,蒋鸿涛..巨噬细胞与异种移植[J].器官移植,2025,16(4):495-501,7.基金项目
国家自然科学基金(82260154、82460153、82400891) （82260154、82460153、82400891）
国家重点研发计划(2024YFC3406800、2023YFC3404304) （2024YFC3406800、2023YFC3404304）
海南省研究生创新科研项目(Qhys2023-438) （Qhys2023-438）
