器官移植2025，Vol.16Issue(4)：502-508,7.DOI:10.12464/j.issn.1674-7445.2025082
类器官芯片在异种器官移植中的应用前景
Application prospects of organoid-on-chips technology in xenotransplantation
摘要
Abstract
Xenotransplantation is an important approach to addressing the shortage of donor organs.However,it still faces numerous challenges,such as acute rejection and zoonotic diseases.Organoid-on-a-chip technology refers to a microcell culture device that simulates the physiological functions of human organs in vitro.In recent years,it has achieved a series of important results in the field of allotransplantation and has great application prospects in the field of xenotransplantation,bringing new opportunities for xenotransplantation research.Therefore,this article discusses the current research status and progress of organoid-on-a-chip technology,combined with the various problems faced by xenotransplantation,to explore the application of organoid-on-a-chip technology in solving the selection of immunosuppressive regimens,matching and viral reactivation in xenotransplantation.This aims to open up new avenues for solving the current problems in the field of xenotransplantation and promote its further development.关键词
类器官芯片/异种移植/器官移植/基因修饰猪/配型/免疫抑制/排斥反应/病毒Key words
Organoid-on-a-chip/Xenotransplantation/Organ transplantation/Genetically modified pig/Matching/Immunosuppression/Rejection/Virus分类
医药卫生引用本文复制引用
林禧龙,王玉,彭江,魏红江,孙圣坤..类器官芯片在异种器官移植中的应用前景[J].器官移植,2025,16(4):502-508,7.基金项目
国家重点研发计划(2019YFA0110701) （2019YFA0110701）
