器官移植2025，Vol.16Issue(4)：509-515,7.DOI:10.12464/j.issn.1674-7445.2025127
新型脱敏措施在ABO血型不合肝移植中的应用现状及展望
Current status and prospects of new desensitization measures in ABO-incompatible liver transplantation
摘要
Abstract
In the field of liver transplantation,due to the shortage of donor livers,ABO-incompatible donor livers,as a type of marginal donor livers,have expanded the source of donors for end-stage renal disease patients who are on the brink of death while waiting for liver transplantation.With the continuous progress of various desensitization techniques in the perioperative period,desensitization treatment for ABO-incompatible liver transplantation has achieved certain effects,but the incidence of postoperative complications remains high.In recent years,with the emergence of new desensitization measures,the therapeutic effect of ABO-incompatible liver transplantation has been further improved,but the mechanisms of action and the synergistic effects of drugs still need to be further explored.Given this,this article provides a review of the mechanisms of action,current clinical applications and future development directions of various new desensitization measures.It aims to explore the feasibility of different desensitization measures in ABO-incompatible liver transplantation,provide supporting evidence for clinical application,and thereby improve the prognosis of liver transplant recipients.关键词
新型脱敏措施/ABO血型不合/肝移植/抗体介导的排斥反应/双重滤过血浆置换/抗体依赖细胞介导的细胞毒作用/骨髓间充质干细胞/脂肪间充质干细胞Key words
New desensitization measure/ABO-incompatibility/Liver transplantation/Antibody-mediated rejection/Double filtration plasmapheresis/Antibody-dependent cell-mediated cytotoxicity/Bone marrow-mesenchymal stem cell/Adipose derived-mesenchymal stem cell分类
医药卫生引用本文复制引用
方腾,张武..新型脱敏措施在ABO血型不合肝移植中的应用现状及展望[J].器官移植,2025,16(4):509-515,7.基金项目
国家重点研发计划(2022YFC2304405) （2022YFC2304405）
