皮肤性病诊疗学杂志2025，Vol.32Issue(6)：383-390,8.DOI:10.3969/j.issn.1674-8468.2025.06.001
血清ANGPT2、IL-23及YKL-40在寻常型银屑病中呈升高状态且与病情程度相关
The elevated levels of serum ANGPT2,IL-23,and YKL-40 and their correlation with the severity of psoriasis vulgaris
摘要
Abstract
Objective To investigate the expression levels of serum angiopoietin-2(ANGPT2),interleukin-23(IL-23),and chitinase-3 like-1 protein(YKL-40)in patients with psoriasis vulgaris and their relationship with disease activity.Methods A total of 96 patients with psoriasis vulgaris treated at Nanyang Central Hospital from October 2020 to October 2023 were se-lected as the case group,while 50 healthy volunteers served as the normal control group.Based on the psoriasis area and severity index(PASI),the case group was divided into mild,moderate,and severe subgroups.The differences in serum ANGPT2,IL-23,and YKL-40 levels between the case group and the normal control group,as well as among patients with different disease severity,were compared.The diagnostic value of serum ANGPT2,IL-23,and YKL-40,along with their combined detection,in assessing severity of psoriasis vulgaris was analyzed.Results Compared with the normal controls,the serum levels of ANGPT2,IL-23,and YKL-40 in the case group were significantly increased(P＜0.05).Logistic regression analysis showed that elevated serum levels of ANGPT2,IL-23,and YKL-40 were associated with the onset of psoriasis vulgaris(P＜0.05).The severe group had higher serum levels of ANGPT2,IL-23,and YKL-40 than the moderate and mild groups,while the moderate group had higher levels than the mild group(P＜0.05).In-creased erythrocyte sedimentation rate(ESR)and elevated serum levels of ANGPT2,IL-23,and YKL-40 were correlated positively with disease severity(P＜0.05).Pearson correlation analysis showed a positive correlation between serum levels of ANGPT2,IL-23,and YKL-40(r=0.47,0.81,respectively,both P＜0.001).ROC curve analysis indicated that serum levels of ANGPT2,IL-23,and YKL-40 had diagnostic value for disease severity in moderate-to-severe psoriasis vul-garis,with the highest diagnostic value observed in their combined detection.Conclusions The levels of serum ANGPT2,IL-23,and YKL-40 are elevated in patients with psoriasis vulgaris,and increase as the disease worsens.Their combined detection has the highest diagnostic value for as-sessing the severity of psoriasis vulgaris.关键词
血管生成素2/白细胞介素-23/几丁质3样蛋白1/寻常型银屑病/疾病活动性/诊断价值Key words
angiopoietin 2/interleukin-23/Chitinase-3 like-1 protein/psoriasis vulgar-is/disease activity/diagnostic value引用本文复制引用
卞坤鹏,翟伟,黄宇锋,闫家笛,梁丽丽..血清ANGPT2、IL-23及YKL-40在寻常型银屑病中呈升高状态且与病情程度相关[J].皮肤性病诊疗学杂志,2025,32(6):383-390,8.基金项目
山西省中医药科研课题立项计划(2024ZYYA033) （2024ZYYA033）
