皮肤性病诊疗学杂志2025，Vol.32Issue(6)：391-396,6.DOI:10.3969/j.issn.1674-8468.2025.06.002
神经梅毒患者血清和脑脊液实验室检测结果及其诊断价值
Laboratory test results of serum and cerebrospinal fluid in patients with neurosyphilis and their diagnostic value
摘要
Abstract
Objective To analyze the laboratory test results of serum and cerebrospinal fluid(CSF)in patients with neurosyphilis(NS)and explore the risk factors for the onset of NS and their diagnostic value.Methods A retrospective analysis was conducted on 264 syphilis patients admitted to the First Affiliated Hospital and the Second Affiliated Hospital of Anhui Medical Uni-versity from August 2020 to August 2024.The patients were divided into two groups:NS group(n=80)and non-NS group(n=184).Comparative analysis was performed on gender,age,and laboratory test results of serum and CSF.Statistical analysis was conducted using SPSS software,with multivariate logistic regression analysis and predictive accuracy assessment applied to factors showing significant differences in univariate analysis.Results Compared with the non-NS group,the NS group had a higher proportion of males,older age,elevated blood glucose,and increased serum levels of ALT,total bilirubin,and creatinine.Although serum levels of ALT,total biliru-bin,and creatinine were increased,they generally fluctuated within the normal reference range.Significant(P＜0.05)were observed in CSF parameters,including TPPA positivity rate,TRUST positivity rate,albumin,white blood cell count,IgG,Pandy's test positivity rate,and albumin quotient.Multivariate logistic regression analysis revealed that age,blood glucose,CSF albumin,white blood cell count,IgG,Pandy's test positivity,and albumin quotient were statistically signifi-cant(P＜0.05).ROC curve analysis of these risk factors showed that CSF albumin,white blood cell count,IgG,and albumin quotient had higher AUC and sensitivity values.Conclusions Male patients,older age,and increased blood glucose levels are associated with a higher risk of developing NS.CSF albumin,white blood cell count,IgG,Pandy's test positivity,and albumin quotient can improve the diagnostic accuracy of NS,with CSF IgG demonstrating the highest diag-nostic sensitivity.Early CSF puncture examination is recommended for timely detection and treat-ment of neurosyphilis.关键词
神经梅毒/脑脊液/免疫球蛋白/梅毒/血清Key words
neurosyphilis/cerebrospinal fluid/immunoglobulin/syphilis/serum引用本文复制引用
高平平,张小龙,孙喆,张冉,王静..神经梅毒患者血清和脑脊液实验室检测结果及其诊断价值[J].皮肤性病诊疗学杂志,2025,32(6):391-396,6.基金项目
安徽省高等学校省级质量工程项目(2022jyxm740) （2022jyxm740）
安徽省高校自然科学研究项目(KJ2020A0186) （KJ2020A0186）
安徽医科大学校科研基金项目(2018xkj039,2022xkj185) （2018xkj039,2022xkj185）
