神经病学与神经康复学杂志2025，Vol.21Issue(3)：167-176,10.DOI:10.12022/jnnr.2025-0112
基于中枢传导通路与姿势控制理论的神经调控诊疗技术的基本原理及临床应用
Fundamental principle of neuromodulation diagnosis and treatment technology based on the theory of central pathways and posture control and its clinical application
何琳 1陈意 1谭惠心 1江汉宏 1何康 2魏意欣 2魏清川 1宋慧妍 1高强1
作者信息
- 1. 四川大学华西医院康复医学中心,四川 成都 610041||四川大学华西医院康复医学研究所,四川 成都 610041||康复医学四川省重点实验室,四川 成都 610041
- 2. 四川大学华西医院康复医学中心,四川 成都 610041||康复医学四川省重点实验室,四川 成都 610041
- 折叠
摘要
Abstract
Neurological disorders such as stroke and Parkinson's disease often lead to postural control and balance dysfunction.Traditional neuromodulation techniques primarily target the cerebral cortex,while research on modulation techniques and mechanisms involving the cerebellum and other neural circuits for postural control remains insufficient.Neuromodulation based on the theory of central pathways and posture control(CPPC)integrates sensory inputs including visual,vestibular and proprioceptive with multi-level neural pathways(e.g.medial and lateral motor systems),in combined with neuroplasticity mechanisms,to provide precise interventions for motor dysfunction.CPPC approach employs multimodal approaches,including transcranial magnetic stimulation(TMS),transcranial direct current stimulation(tDCS),and repetitive peripheral magnetic stimulation(rPMS).It adheres to 4 principles,which are internal and external synergy,proximal-distal integration,multi-dimensional reconstruction and compliance with physiological principles.By targeting the cerebellum,core muscle groups and cortico-spinal pathways,CPPC-based neuromodulation techniques have demonstrated significant improvements in patients'balance and motor function.Clinical studies have shown that CPPC approach enhances neural remodeling and functional recovery through central-peripheral synergistic intervention and temporal coordination strategies.Future research should explore individualized target localization,dose-response relationships and mechanism of multimodal integration to improve the establishment of precision rehabilitation systems.CPPC approach provides new ideas for neurological rehabilitation and has significant implications on both clinical treatment and research.关键词
神经康复/神经调控/平衡/姿势控制/中枢传导通路与姿势控制Key words
Neurorehabilitation/Neuromodulation/Balance/Posture control/Central pathways and postural control引用本文复制引用
何琳,陈意,谭惠心,江汉宏,何康,魏意欣,魏清川,宋慧妍,高强..基于中枢传导通路与姿势控制理论的神经调控诊疗技术的基本原理及临床应用[J].神经病学与神经康复学杂志,2025,21(3):167-176,10.
