神经病学与神经康复学杂志2025，Vol.21Issue(3)：201-214,14.DOI:10.12022/jnnr.2025-0114
有氧运动对不同年龄帕金森病患者临床症状和肠道菌群的影响
Effects of aerobic exercise on clinical symptoms and gut microbiota in Parkinson's disease patients of different age groups
摘要
Abstract
Objective:To investigate the effects of aerobic exercise on clinical symptoms and gut microbiota in Parkinson's disease(PD)patients of different age groups. Methods:This study included 21 PD patients,divided into age groups of<60 years and≥60 years,and underwent an 8-week moderate intensity aerobic exercise intervention.Assess patients with relevant scales before and after intervention,and collect their feces for 16S ribosomal RNA amplicon sequencing and statistical analysis. Results:Only UPDRS-III on-off and total scores showed statistically significant improvement in<60 years old PD patients after aerobic exercise intervention(P=0.042,P=0.021);UPDRS-II,UPDRS-III on,UPDRS-III off,UPDRS total scores,Berg Balance Scale(BBS)and Tinetti Performance Oriented Mobility Assessment(Tinetti POMA)improved in≥60 years old PD patients(the P values were 0.029,<0.001,0.025,<0.001,0.008 and 0.023 respectively).In addition,after aerobic exercise intervention,the Mini Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),PD Questionnaire 39(PDQ-39),Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire(RBDSQ),Scales for Outcomes in PD Autonomous(SCOPA-AUT),Gastrointestinal Dysfunction Score(Gastrointestinal Dysfunction Score),Gastrointestinal Dysfunction Score(GIDS),Hamilton Anxiety Rating Scale(HAMA),Hamilton Depression Rating Scale(HAMD)and Non Motor Symptoms Scale(NMSS)scores were improved in≥60 years old PD patients(P values were 0.002,0.006,0.002,0.016,0.007,0.029,0.002,0.008,and 0.003,respectively).The NMSS score of PD patients in the<60 age group improved and the difference was statistically significant(P=0.044)after intervention.Gut microbiota analysis revealed the relative abundance of Fusicatenibacter and Erysipelotrichaceae_UCG-003 were increased in the PD group aged<60 years after aerobic exercise intervention,and the difference was statistically significant compared with the pre-intervention period(Z values were-2.201 and-2.207,and P values were 0.028 and 0.027,respectively). Conclusion:Moderate-intensity aerobic exercise can improve motor symptoms as well as non-motor symptoms such as cognition,quality of life,sleep,autonomic function,anxiety and depression in PD patients of different age groups.Notably,moderate-intensity aerobic exercise can improve the relative abundance of beneficial gut microbiota,particularly in<60 years old patients.关键词
有氧运动/帕金森病/运动症状/非运动症状/肠道菌群Key words
Aerobic exercise/Parkinson's disease/Motor symptom/Non-motor symptom/Gut microbiota引用本文复制引用
韦泉清,王惠,刘于宁,王凤丽,吴鑫,徐传英,崔桂云,项洁..有氧运动对不同年龄帕金森病患者临床症状和肠道菌群的影响[J].神经病学与神经康复学杂志,2025,21(3):201-214,14.基金项目
国家重点研发计划(2020YF2006604) （2020YF2006604）
江苏省基础研究计划自然科学基金——面上项目(BK20241770) National Key Research and Development Program(2020YF2006604) （BK20241770）
Natural Science Foundation of Jiangsu Province Basic Research Program-General Project(BK20241770) （BK20241770）
