神经病学与神经康复学杂志2025，Vol.21Issue(3)：215-222,8.DOI:10.12022/jnnr.2025-0096
重复经颅磁刺激联合运动训练改善小脑性共济失调患者运动功能的疗效观察:系列病例分析
Observation on the Efficacy of repetitive transcranial magnetic stimulation combined with exercise training on improving motor function in patients with cerebellar ataxia:A case series study
摘要
Abstract
Objective:To investigate the effects of repetitive transcranial magnetic stimulation(rTMS)combined with exercise training on balance function,coordination function,walking function,and activities of daily living in patients with cerebellar ataxia. Methods:Four patients with cerebellar ataxia were enrolled,and they received a 15-day intervention of rTMS(high-frequency 5Hz stimulation targeting the cerebellar vermis,once daily for 20 minutes per session)combined with exercise training(twice daily for 30 minutes per session).Rehabilitation assessments were conducted before and after the intervention,including muscle strength(manual muscle testing,MMT),balance function(Berg balance scale,BBS),coordination function(finger-to-nose test,alternating movement test,heel-knee-shin test),walking function(Holden functional ambulation classification,FAC),and activities of daily living(modified Barthel index,MBI). Results:After the intervention of rTMS combined with exercise training,all four patients showed improvements in MMT grade,BBS scores and MBI scores,three patients showed improvements in FAC grades.Results of finger-to-nose test,alternating movement test,and heel-knee-shin test demonstrated significant improvements in coordination function for all patients. Conclusion:rTMS combined with exercise training can enhance balance function,coordination function,walking function,and activities of daily living in patients with cerebellar ataxia.关键词
重复性经颅磁刺激/运动训练/小脑性共济失调/协调功能/步行功能Key words
Repetitive transcranial magnetic stimulation/Exercise training/Cerebellar ataxia/Coordination function/Walking function引用本文复制引用
钟倩,洪文军,王宇,徐蓉..重复经颅磁刺激联合运动训练改善小脑性共济失调患者运动功能的疗效观察:系列病例分析[J].神经病学与神经康复学杂志,2025,21(3):215-222,8.基金项目
南京鼓楼医院临床研究专项资金项目(2022-LCYJ-PY-27) Naning Drum Tower Hospital Clinical Research Special Fund Project(2022-LCYJ-PY-27) （2022-LCYJ-PY-27）
