神经病学与神经康复学杂志2025，Vol.21Issue(3)：223-231,9.DOI:10.12022/jnnr.2025-0093
视神经脊髓炎谱系疾病的功能障碍及康复治疗进展
Advances in dysfunction and rehabilitation treatment of neuromyelitis optica spectrum disorder
摘要
Abstract
Neuromyelitis optica spectrum disorder(NMOSD)is a recurrent inflammatory demyelinating disease of the central nervous system,mainly affecting the optic nerve and spinal cord,with clinical manifestations such as decreased visual acuity,dyskinesia,pain,vesico-rectal dysfunction,cognitive dysfunction,and so on.It is characterized by high recurrence rate,high disability rate and long disease duration,which seriously affects patients'quality of life.Although recent advances in diagnostic and therapeutic techniques have improved the prognosis of NMOSD patients,most patients are still left with different degrees of dysfunction,and systematic rehabilitation interventions are urgently needed.Based on the existing research evidence,this review details the common dysfunctions of NMOSD and their pathological mechanisms,including visual dysfunction,spinal cord damage-related dysfunctions(dyskinesia,pain,and vesico-rectal dysfunction),and cognitive dysfunction.Meanwhile,it focuses on the latest advances in rehabilitation therapy of NMOSD,covering multidisciplinary and integrated intervention strategies of physical therapy,occupational therapy,psychological intervention and the application of emerging technologies[e.g.,brain-computer interface(BCI),brain-spinal interface(BSI),etc.],with the aim of providing a theoretical basis and practical guidance for the clinical rehabilitation practice of NMOSD patients.关键词
视神经脊髓炎谱系疾病/功能障碍/运动障碍/疼痛/康复Key words
Neuromyelitis optica spectrum disorder/Dysfunction/Dyskinesia/Pain/Rehabilitation引用本文复制引用
李鑫怡,叶琳琳,李芳,曹磊..视神经脊髓炎谱系疾病的功能障碍及康复治疗进展[J].神经病学与神经康复学杂志,2025,21(3):223-231,9.基金项目
北京市卫生健康委员会研究型病房卓越临床研究计划平行项目(BRWEP2024W022010111) The parallel project of the Beiing Municipal Health Commission Research Ward Excellence Program in Clinical Research(BRWEP2024W022010111) （BRWEP2024W022010111）
