Dharmalingam Kirubakaran1
作者信息
- 1. Department of Pharmacology,Saveetha Medical College and Hospital,Saveetha Institute of Medical and Technical Sciences(SIMATS),Saveetha University,Chennai,Tamil Nadu 602105,India
- 折叠
摘要
Abstract
Alzheimer's disease(AD)is a progressive neurodegenerative condition characterized by memory loss and cognitive decline.Current drugs offer limited benefits and often cause side effects.Recently,interest has grown in medicinal plants for the treatment of AD due to their neuroprotective compounds.This review explores how herbal remedies may help AD,focus-ing on key plants including Ginkgo biloba,Curcuma longa,Withania somnifera,and Panax ginseng.These plants show promise in reducing inflammation,oxidative stress,and amyloid buildup.Their bioactive compounds,including flavonoids and alkaloids,may promote mem-ory and slow AD progression.Despite these promising findings,the review also highlights sig-nificant challenges in translating preclinical success into clinical efficacy.Issues such as vari-ability in plant composition,lack of standardized formulations,insufficient large-scale clini-cal trials,and regulatory hurdles continue to impede the integration of herbal therapies into mainstream AD treatment.Addressing these challenges through rigorous scientific validation and standardized protocols is essential for advancing the use of herbal medicine in neurode-generative disease management.关键词
阿尔茨海默病/神经保护机制/药用植物/植物化学成分/氧化应激Key words
Alzheimer's disease/Neuroprotective mechanisms/Medicinal plants/Phytochemicals/Oxidative stress
