现代妇产科进展2025，Vol.34Issue(7)：511-516,6.DOI:10.13283/j.cnki.xdfckjz.2025.07.006
抗磷脂抗体对SLE及UCTD患者妊娠结局的影响
Retrospective analysis of the impact of antiphospholipid antibodies on pregnancy out-comes in 101 patients with SLE and UCTD
摘要
Abstract
Objective:To analyze the impact of antiphospholipid antibodies(aPL)on ultrasound-detected adverse events(AE),medication regimens,and adverse pregnancy out-comes(APO)in pregnant patients with systemic lupus erythematosus(SLE)and undifferentiat-ed connective tissue disease(UCTD).Methods:A retrospective analysis was conducted on clin-ical data from 47 SLE patients and 54 UCTD patients with singleton pregnancies.Results:SLE patients with aPL had significantly longer disease duration[4.0(2.0,10.3)years]than UCTD patients[1.0(0.0,4.3)years].In the second trimester,18/28 patients(64.3%)in the UCTD_aPL+group experienced adverse events(AEs),which was significantly higher than the 6/26 patients(23.1%)in the UCTD_aPL-group.Additionally,the SLE group had a signifi-cantly higher number of patients with positive urine protein and a higher urine total protein-to-creatinine ratio(Pr/Cr)compared to the UCTD group.Low neonatal birth weight was the most common APO,though incidence rates did not differ significantly between groups.However,aPL positivity strongly correlated with APO:UCTD patients with fetal APO had a lupus anticoagulant(LA)positivity rate of 62.5%was significantly higher than the 21.7%,in UCTD patients without APO.SLE patients with APO exhibited a second-trimester fetal growth restriction(FGR)rate of 41.7%,was significantly higher than the 11.4%in SLE patients without APO.Logistic regression analysis identified the following APO risk factors:SLE patients positive for aCL-IgG antibodies faced increased odds of fetal adverse pregnancy events(P=0.016).LA-positive UCTD patients showed heightened fetal APO risk(P=0.017).Conclusion:aPL posi-tivity is significantly associated with adverse pregnancy outcomes(APOs)in SLE patients,while fetal growth restriction(FGR)during pregnancy is significantly linked to APOs in UCTD patients.Prompt anticoagulation and intensified immunosuppressive therapy may serve as sal-vage measures to mitigate adverse outcomes.关键词
未分化结缔组织病/系统性红斑狼疮/抗磷脂抗体/妊娠/不良妊娠结局Key words
Undifferentiated connective tissue diseases/Systemic lupus erythemato-sus/Antiphospholipid/Pregnancy/Adverse pregnancy outcome分类
医药卫生引用本文复制引用
任冰冰,刘雪娜,舒强,赵颖杰,马莹莹,谢珂珂,刘媛,马玉燕,方燕,邱晓群,李霞..抗磷脂抗体对SLE及UCTD患者妊娠结局的影响[J].现代妇产科进展,2025,34(7):511-516,6.基金项目
山东大学临床研究项目(No:2021SDUCRCB010) （No:2021SDUCRCB010）
山东省自然科学基金项目(No:ZR2023MH234) （No:ZR2023MH234）
