现代妇产科进展2025，Vol.34Issue(7)：517-521,527,6.DOI:10.13283/j.cnki.xdfckjz.2025.07.007
维生素D相关基因在孕产妇中的表达变化及对早产的预测价值
Alterations in the expression of vitamin D-related genes in pregnant women and their predictive value for premature birt
摘要
Abstract
Objective:To investigate changes in the expression of genes associated with vitamin D in pregnant women and assesses their potential for predicting preterm birth.Meth-ods:From September 2021 to June 2024,a total of 506 pregnant women were admitted to the obstetrics department of Xingtai Central Hospital,of which 253 were spontaneous preterm deliv-ery cases(gestational age range 28 to 37 weeks),constituting the premature group;another 253 pregnant women who delivered at full term during the same period(gestational age more than 37 weeks)were taken as the control group.The frequency distribution of vitamin D-related gen-otypes was compared in the premature group and the control group.The potential risk factors for spontaneous preterm birth were further explored by univariate analysis and logistic regression model.In addition,the ROC curve was used to evaluate the efficacy of vitamin D-related genes in predicting spontaneous preterm birth in pregnant women.Results:The gestational age,cervi-cal length,and neonatal birth weight were significantly lower in the preterm birth group com-pared to the control group(P<0.001),the white blood cell count,neutrophil count,and lym-phocyte count were significantly elevated in the preterm group(P<0.001).Genotypic distribu-tion analysis showed that the proportion of the GG genotype at the rs7975232 locus was higher in the preterm group than that in the control group(52.18%vs 17.78%,P<0.001),as were the AA genotype at rs2228570(40.71%vs 24.11%,P<0.001)and the TT genotype at rs2282679(44.27%vs 24.11%,P<0.001).Logistic regression analysis identified three vari-ables significantly associated with the risk of spontaneous preterm birth(P<0.05):the GG gen-otype at rs7975232,the AA genotype at rs2228570,and the TT genotype at rs2282679.The lo-gistic regression model was formulated as follows:logit(P)=-0.787+0.551X1+0.449X2+0.981X3,where X1 represents the GG genotype at rs7975232,X2 the AA genotype at rs2228570,and X3 the TT genotype at rs2282679.The ROC curve analysis yielded a sensitivity of 60.87%and specificity of 79.84%for the GG genotype at rs7975232,with an AUC of 0.705(95%CI:0.659～0.751).The AA genotype at rs2228570 exhibited a sensitivity of 60.47%,specificity of 58.89%,and an AUC of 0.631(95%CI:0.583～0.679),while the TT genotype at rs2282679 showed a sensitivity of 53.75%,specificity of 54.15%,and an AUC of 0.519(95%CI:0.468～0.569).Overall,the regression model demonstrated a sensitivity of 86.17%and specificity of 83.79%,with an AUC of 0.912(95%CI:0.889～0.935).Con-clusion:The abnormal expression of vitamin D-related gene single nucleotide polymorphisms at loci rs7975232,rs2228570,and rs2282679 may serve as influential factors in spontaneous pre-term birth.These SNPs could potentially be applied as predictive markers for spontaneous pre-term birth,warranting further clinical research and broader application.关键词
维生素D相关基因/妊娠期妇女/早产/预测价值Key words
Vitamin D-related genes/Pregnant women/Premature birth/Predictive value分类
医药卫生引用本文复制引用
王文丽,吴棣,孙红,高佳丽,高妍..维生素D相关基因在孕产妇中的表达变化及对早产的预测价值[J].现代妇产科进展,2025,34(7):517-521,527,6.基金项目
邢台市重点研发计划项目(No:2022ZC233) （No:2022ZC233）
