摘要
Abstract
Objective To investigate the relationship between gingival crevicular fluid galectin-3(Gal-3),asprosin and prog-nosis of patients with periimplantitis(PI).Methods A total of 138 patients with PI admitted to the Third Medical Center of PLA Gen-eral Hospital from January 2021 to December 2023 were selected as the disease group,and were divided into a poor group(44 cases)and a good group(94 cases)according to their prognosis.Another 138 healthy implant patients were selected as a control group.The levels of Gal-3 and asprosin in gingival crevicular fluid were compared.The correlation between the levels of Gal-3 and asprosin in gin-gival crevicular fluid and periodontal clinical indicators was analyzed using Pearson's method.Multivariate logistic regression was ap-plied to analyze the influencing factors of poor prognosis in PI patients.ROC curve was used to analyze the predictive value of gingival crevicular fluid Gal-3 and asprosin levels combined with periodontal clinical indicators for poor prognosis in PI patients.Results Com-pared with control group,the levels of Gal-3 and asprosin in gingival crevicular fluid and periodontal clinical indicators in the disease group were significantly increased(P<0.05).The levels of Gal-3 and asprosin in gingival crevicular fluid were positively correlated with periodontal clinical indicators(P<0.05).Compared with the good group,the levels of Gal-3 and asprosin and periodontal clinical indicators were greatly higher in the poor group(P<0.05).The area under the curve(AUC)of Gal-3,asprosin levels,PD,mGI,and mSBI combined in predicting poor prognosis in PI patients was significantly higher than that predicted by a single indicator(Z com-bined prediction-Gal-3=2.892,Z combined prediction-sprosin=2.062,Z combined prediction-PD=2.710,Z combined prediction-mGI=2.929,Z combined prediction-mSBI=3.017,P=0.004,0.039,0.007,0.003,0.003).Conclusions Gingival crevicular fluid Gal-3 and asprosin levels combined with periodontal clinical indicators have high predictive value for poor prognosis in PI pa-tients.关键词
种植体周围炎/半乳糖凝集素-3/白脂素/牙周临床指标Key words
periimplantitis/galectin-3/asprosin/periodontal clinical indicators分类
医药卫生
