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Targeting ceramide-induced microglial pyroptosis:Icariin is a promising therapy for Alzheimer's disease

Hongli Li Qiao Xiao Lemei Zhu Jin Kang Qiong Zhan Weijun Peng

药物分析学报（英文）2025，Vol.15Issue(4)：786-803,18.

药物分析学报（英文）2025，Vol.15Issue(4)：786-803,18.DOI:10.1016/j.jpha.2024.101106

Targeting ceramide-induced microglial pyroptosis:Icariin is a promising therapy for Alzheimer's disease

Hongli Li ¹Qiao Xiao ¹Lemei Zhu ¹Jin Kang ²Qiong Zhan ³Weijun Peng¹

作者信息

1. Department of Integrated Traditional Chinese & Western Medicine,The Second Xiangya Hospital of Central South University,Changsha,410011,China||National Clinical Research Center for Metabolic Diseases,Changsha,410011,China
2. Department of Rheumatology and Immunology,The Second Xiangya Hospital of Central South University,Changsha,410011,China
3. Department of Neurology,The Second Xiangya Hospital of Central South University,Changsha,410011,China||Clinical Medical Research Center for Stroke Prevention and Treatment of Hunan Province,Department of Neurology,The Second Xiangya Hospital of Central South University,Changsha,410011,China
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摘要

关键词

Alzheimer's disease/Ceramides/Microglia pyroptosis/COX2/NLRP3 inflammasome/Icariin

Key words

Alzheimer's disease/Ceramides/Microglia pyroptosis/COX2/NLRP3 inflammasome/Icariin

引用本文复制引用

Hongli Li,Qiao Xiao,Lemei Zhu,Jin Kang,Qiong Zhan,Weijun Peng..Targeting ceramide-induced microglial pyroptosis:Icariin is a promising therapy for Alzheimer's disease[J].药物分析学报（英文）,2025,15(4):786-803,18.

基金项目

This work was financially supported by the National Natural Science Foundation of China(Grant No.:82374552),Hunan Pro-vincial Natural Science Foundation of China for Distinguished Young Scholars(Grant No.:2024JJ2086),the Science and Technol-ogy Innovation Program of Hunan Province,China(Grant No.:2022RC1220),and Support Plan for High-level Health and Medical Talents in Hunan Province,China. （Grant No.:82374552）

药物分析学报（英文）

ISSN：2095-1779

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