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Tailoring a traditional Chinese medicine prescription for complex diseases:A novel multi-targets-directed gradient weighting strategy

Zhe Yu Yang Wang Jiekun Luo Xueping Yang Tao Tang En Hu Teng Li Zhi Zheng Xiya Yang Xin Guo Xindi Zhang Haoying Jiang Lin Zhu Bo Yang

药物分析学报（英文）2025，Vol.15Issue(4)：804-816,13.

药物分析学报（英文）2025，Vol.15Issue(4)：804-816,13.DOI:10.1016/j.jpha.2025.101199

Tailoring a traditional Chinese medicine prescription for complex diseases:A novel multi-targets-directed gradient weighting strategy

Zhe Yu ¹Yang Wang ¹Jiekun Luo ¹Xueping Yang ¹Tao Tang ²En Hu ²Teng Li ¹Zhi Zheng ³Xiya Yang ¹Xin Guo ⁴Xindi Zhang ¹Haoying Jiang ¹Lin Zhu ¹Bo Yang¹

作者信息

1. Institute of Integrative Medicine,Department of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha,410008,China
2. Institute of Integrative Medicine,Department of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Jiangxi(National Regional Center for Neurological Diseases),Nanchang,330038,China||NATCM Key Laboratory of TCM Gan,Xiangya Hospital,Central South University,Changsha,410008,China||National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,410008,China
3. Department of Neurology,Xiangya Hospital,Central South University,Jiangxi(National Regional Center for Neurological Diseases),Nanchang,330038,China||Jiangxi Provincial People's Hospital,The First Affiliated Hospital of Nanchang Medical College,Nanchang,330038,China
4. Institute of Integrative Medicine,Department of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha,410008,China||The First Affiliated Hospital,Children's Medical Centre,Hengyang Medical School,University of South China,Hengyang,Hunan,421001,China
折叠

摘要

关键词

Traditional Chinese medicine/Prescription formulation/Gradient weighting strategy/Multiple targets/Intracerebral hemorrhage

Key words

Traditional Chinese medicine/Prescription formulation/Gradient weighting strategy/Multiple targets/Intracerebral hemorrhage

引用本文复制引用

Zhe Yu,Yang Wang,Jiekun Luo,Xueping Yang,Tao Tang,En Hu,Teng Li,Zhi Zheng,Xiya Yang,Xin Guo,Xindi Zhang,Haoying Jiang,Lin Zhu,Bo Yang..Tailoring a traditional Chinese medicine prescription for complex diseases:A novel multi-targets-directed gradient weighting strategy[J].药物分析学报（英文）,2025,15(4):804-816,13.

基金项目

This work was supported by the National Natural Science Foundation of China(Grant Nos.:82174259 and 82304997),China Postdoctoral Followship Program of CPSF(Grant No.:GZC20233202),China Postdoctoral Science Foundation(Grant No.:2024M753698),the Key Research and Development Program of Hunan Province of China(Grant Nos.:2023SK2021 and 2022SK2015),the Natural Science Foundation of Hunan Province,China(Grant Nos.:2024JJ6632,2022JJ40853,and 2021JJ31117),the Hunan Traditional Chinese Medicine Scientific Research Program,China(Grant Nos.:B2024113,B2024114,and 2021032),and the Fundamental Research Funds for the Central Universities of Central South University,China(Grant No.:1053320232786).We thank Novogene Co.,Ltd.for the RNA sequencing services,Biotree Biomedical Technology Co.,Ltd.for compound detection,and the BioRender platform(https://www.biorender.com)for providing the icons used in Fig.1. （Grant Nos.:82174259 and 82304997）

药物分析学报（英文）

ISSN：2095-1779

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