摘要
Abstract
Autoimmune encephalitis(AE)refers broadly to a group of encephalitic disorders mediated by autoim-mune mechanisms.AE is characterized by complex pathogeneses and diverse clinical manifestations,and there are still numerous challenges in the diagnosis and treatment of AE.With the development of frontier technologies such as vac-cines,gene editing,and big data,new opportunities have emerged for transforming the diagnosis and treatment strategies for AE.Vaccines play a dual role in AE:on the one hand,they can prevent infections;on the other hand,they may trig-ger autoimmune responses through molecular mimicry.Emerging nanovaccine technologies are expected to achieve safer and more effective immunomodulation.Gene editing techniques,especially the CRISPR-Cas9 system,have shown poten-tial in targeted regulation of the function of immune cells and repair of nervous tissue,which provides new pathways for pre-cise intervention in the treatment of AE.The application of big data technologies,including artificial intelligence,natural language processing,and deep learning,has promoted the early diagnosis of AE and the development of individualized treatment regimens.This article reviews the research advances and clinical prospects of these cutting-edge technologies in AE,in order to provide insights and references for the development of precision medicine,interdisciplinary collaboration,and future treatment strategies for AE.关键词
自身免疫性脑炎/疫苗/基因编辑/大数据Key words
Autoimmune encephalitis/Vaccine/Gene editing/Big data分类
医药卫生
