中风与神经疾病杂志2025，Vol.42Issue(6)：501-508,8.DOI:10.19845/j.cnki.zfysjjbzz.2025.0095
抗体介导的神经免疫反应:自身免疫性脑炎的机制进展
Antibody-mediated neuroimmune response:Advances in the mechanism of autoimmune encephalitis
摘要
Abstract
Autoimmune encephalitis(AE)is a group of antibody-mediated inflammatory disorders that target neuro-nal antigens,with the main symptoms of mental and behavioral disorders,epilepsy,and cognitive impairment.In recent years,specific antibodies,such as anti-NMDAR antibody and anti-LGI1 antibody,have played an important role in the pathogenesis of AE and have become effective biomarkers,which have significantly improved the early detection rate of AE.As novel antibodies continue to be discovered,the pathological mechanisms of AE are constantly clarified,providing new directions for precision treatment.Nevertheless,there are still challenges in the mechanism of action and clinical ap-plication of these emerging antibodies,requiring support from more basic studies and clinical data.This article discusses the role of antibodies in AE,analyzes the types of newly discovered antibodies and their role in disease progression,and explores the potential and challenges of antibodies used as tools for precise diagnosis and targeted therapy.关键词
自身抗体/自身免疫性脑炎/发病机制Key words
Autoantibody/Autoimmune encephalitis/Pathogenesis分类
医药卫生引用本文复制引用
于蕾,李航,温瑶,任丹,丁聪,郑文旭..抗体介导的神经免疫反应:自身免疫性脑炎的机制进展[J].中风与神经疾病杂志,2025,42(6):501-508,8.基金项目
大连市重点学科"登峰计划"资助项目(FH2021002,FH2022001) （FH2021002,FH2022001）
大连市生命健康领域指导计划项目(2023JJ13SNYY) （2023JJ13SNYY）
