中风与神经疾病杂志2025，Vol.42Issue(6)：512-516,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0097
抗LGI1抗体自身免疫性脑炎的临床分析
Clinical features of anti-leucine rich glioma inactivated 1 antibody autoimmune encephalitis
摘要
Abstract
Objective To investigate the clinical manifestations and prognosis of patients with anti-leucine rich glioma inactivated 1(LGI1)antibody encephalitis.Methods A retrospective analysis was performed for the data of patients with anti-LGI1 antibody encephalitis who were hospitalized in Department of Neurology,Xuanwu Hospital,Capital Medical University,from September 2019 to December 2023,including clinical features,treatment,and prognosis.Results A total of 80 patients were enrolled,including 48 male patients and 32 female patients.Of all 80 patients,51(63.8%)had the initial symptom of epilepsy,13(16.3%)had the initial symptom of faciobrachial dystonic seizures,26(32.5%)had the initial symptom of cognitive impairment,and 12(15%)had the initial symptom of mental and behavioral disorders.As for comorbidities,there were 28 patients(35%)with hyponatremia,22(27.5%)with Hashimoto's thyroiditis,and 5(6.25%)with tumor.All 80 patients tested positive for serum LGI1 antibody,and 69(86.3%)tested positive for LGI1 antibody in cerebrospinal fluid.Among the 80 patients,37(46.25%)had abnormalities on magnetic resonance imaging,and 30 had abnormalities on 18F-FDG PET/CT.There were 50 patients with abnormalities on video electroencephalography.A total of 77 patients received first-line immunotherapy,and after follow-up for 1 year,19.4%of the patients had the sequela of seizure,59.7%of the patients had deterioration of the memory,and 48.6%of the patients had mental and behavioral disorders.Conclusion Epilepsy,cognitive impairment,and mental and behavior disorders are the most common manifestations of anti-LGI1 antibody encephalitis.There is generally a good prognosis after immunotherapy,with the sequelae of cognitive impairment and mental and behavioral disorders.关键词
自身免疫性脑炎/LGI1抗体/癫痫/认知障碍/精神行为异常Key words
Autoimmune encephalitis/Leucine rich glioma inactivated 1 antibody/Epilepsy/Cognitive impairment/Mental and behavioral disorders分类
医药卫生引用本文复制引用
李永芳,常杰,唐毅,秦琪..抗LGI1抗体自身免疫性脑炎的临床分析[J].中风与神经疾病杂志,2025,42(6):512-516,5.基金项目
国家自然科学基金(82201568) （82201568）
中国科协青年托举人才(2021ZD0201801) （2021ZD0201801）
北京市科技新星(Z211100002121051) （Z211100002121051）
河南省科技攻关项目(252102310281) （252102310281）
郑州市医疗卫生领域科技创新指导计划项目(2024YLZDJH154) （2024YLZDJH154）
